Literature DB >> 26117562

Biarylsulfonamide CCR9 inhibitors for inflammatory bowel disease.

Jing Zhang1, Jan Romero2, Audrey Chan2, Jennifer Goss2, Sabrina Stucka2, Jason Cross2, Brian Chamberlain2, Mustafa Varoglu2, Haoqun Chandonnet2, Dominic Ryan2, Blaise Lippa2.   

Abstract

Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, affects millions of people worldwide. CCR9 has been shown to be a key chemokine receptor mediating the local inflammatory responses in the GI tract. The CCR9 inhibitor Vercirnon advanced to phase 3 clinical trials, but carries several liabilities which we sought to improve.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  CCR9; Crohn’s disease; IBD; Sulfonamide; Ulcerative colitis

Mesh：

Substances：

Year:  2015        PMID： 26117562     DOI： 10.1016/j.bmcl.2015.06.046

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

Review 1.  Consider the chemokines: a review of the interplay between chemokines and T cell subset function.

Authors:  Marianne Strazza; Adam Mor
Journal:  Discov Med       Date:  2017-08       Impact factor: 2.970

2.  In-silico guided discovery of novel CCR9 antagonists.

Authors:  Xin Zhang; Jason B Cross; Jan Romero; Alexander Heifetz; Eric Humphries; Katie Hall; Yuchuan Wu; Sabrina Stucka; Jing Zhang; Haoqun Chandonnet; Blaise Lippa; M Dominic Ryan; J Christian Baber
Journal:  J Comput Aided Mol Des       Date:  2018-03-26       Impact factor: 3.686

3.  Dimethyl Fumarate Reduces Inflammatory Responses in Experimental Colitis.

Authors:  Giovanna Casili; Marika Cordaro; Daniela Impellizzeri; Giuseppe Bruschetta; Irene Paterniti; Salvatore Cuzzocrea; Emanuela Esposito
Journal:  J Crohns Colitis       Date:  2015-12-21       Impact factor: 9.071

4.  Macrophage Subset Expressing CD169 in Peritoneal Cavity-Regulated Mucosal Inflammation Together with Lower Levels of CCL22.

Authors:  Dan Wang; Qiuting Li; Yang Yang; Shengyu Hao; Xiaolei Han; Jia Song; Yue Yin; Xiangzhi Li; Masato Tanaka; Chun-Hong Qiu
Journal:  Inflammation       Date:  2017-08       Impact factor: 4.092

5.  PLCε1 suppresses tumor growth by regulating murine T cell mobilization.

Authors:  M Strazza; K Adam; A V Smrcka; S Lerrer; A Mor
Journal:  Clin Exp Immunol       Date:  2020-01-09       Impact factor: 4.330

6.  A Chemical Biology Toolbox Targeting the Intracellular Binding Site of CCR9: Fluorescent Ligands, New Drug Leads and PROTACs.

Authors:  Max E Huber; Lara Toy; Maximilian F Schmidt; Hannah Vogt; Julian Budzinski; Martin F J Wiefhoff; Nicole Merten; Evi Kostenis; Dorothee Weikert; Matthias Schiedel
Journal:  Angew Chem Int Ed Engl       Date:  2022-01-27       Impact factor: 16.823
  6 in total

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