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Literature DB >> 26117456

Keap1-Nrf2 signalling in pancreatic cancer.

Alastair J Hayes¹, Christos Skouras², Beate Haugk³, Richard M Charnley⁴.

Abstract

Transcription factor NF-E2 p45-related factor 2 (Nrf2, also called Nfe2l2), a master regulator of redox homeostasis, and its dominant negative regulator, Kelch-like ECH-associated protein 1 (Keap1), together tightly control the expression of numerous detoxifying and antioxidant genes. Nrf2 and the 'antioxidant response element' (ARE)-driven genes it controls are frequently upregulated in pancreatic cancer and correlate with poor survival. Upregulation of Nrf2 is, at least in part, K-Ras oncogene-driven and contributes to pancreatic cancer proliferation and chemoresistance. In this review, we aim to provide an overview of Keap1-Nrf2 signalling as it relates to pancreatic cancer, discussing the effects of inhibiting Nrf2 or Nrf2/ARE effector proteins to increase chemosensitivity.

Entities: Disease Gene

Keywords: AKR1B10; Keap1; NQO1; Nrf2; Pancreatic cancer

Mesh：

Substances：

Year: 2015 PMID： 26117456 DOI： 10.1016/j.biocel.2015.06.017

Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085

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Cited

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Keap1-Nrf2 signalling in pancreatic cancer.

Review 1. The roles of E3 ligases in Hepatocellular carcinoma.

2. The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.

3. Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes.

4. Overexpression of NRF2 is correlated with prognoses of patients with malignancies: A meta-analysis.

5. IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway.

6. Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway.

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Review 8. The Role of AKR1B10 in Physiology and Pathophysiology.

9. Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types.

10. NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib.