Peiyan Ni1, Xiaohong Ma2, Yin Lin3, Guohui Lao3, Xiaoyu Hao3, Lijie Guan3, Xuan Li3, Zeyu Jiang3, Yuping Liu3, Biyu Ye3, Xiang Liu4, Yingcheng Wang1, Liansheng Zhao1, Liping Cao5, Tao Li1. 1. Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China. 2. Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, PR China; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address: maxiaohong@scu.edu.cn. 3. Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China. 4. State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, PR China. 5. Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University), Guangzhou, Guangdong, PR China. Electronic address: coolliping@hotmail.com.
Abstract
BACKGROUND: The oxidative stress hypothesis proposed to explain bipolar I disorder (BD I) pathogenesis has gained growing attention based on its association with cognitive impairment. The aim of the present study was to explore the association of the methionine sulfoxide reductase A (MsrA) gene with BD I as well as executive functions of BD I patients. METHODS: A total of 44 tagging single-nucleotide polymorphisms within the MsrA gene were selected to analyze gene association with BD I in 375 BD I patients and 475 controls in a Han Chinese population. The association of MsrA haplotypes with executive functions was analyzed in 157 clinically stable BD I patients and 210 controls. RESULTS: Allele frequencies of the rs4840463 polymorphism were significantly different between BD I patients and controls, and between patients with psychotic symptoms and controls. BD I patients performed more poorly in 11 of the 13 neurocognitive measurements compared with controls. Three MsrA haplotypes showed significant associations with different executive functions. LIMITATIONS: The limited sample size requires a cautious conclusion, and further comprehensive approaches are needed to explore the mechanism of MsrA's effect on BD I. CONCLUSIONS: The rs4840463 polymorphism in the MsrA gene may be associated with the increased risk of BD I in a Chinese population. The association of MsrA haplotypes with executive functions indicated that MsrA is associated with executive function defects in BD I patients.
BACKGROUND: The oxidative stress hypothesis proposed to explain bipolar I disorder (BD I) pathogenesis has gained growing attention based on its association with cognitive impairment. The aim of the present study was to explore the association of the methionine sulfoxide reductase A (MsrA) gene with BD I as well as executive functions of BD I patients. METHODS: A total of 44 tagging single-nucleotide polymorphisms within the MsrA gene were selected to analyze gene association with BD I in 375 BD I patients and 475 controls in a Han Chinese population. The association of MsrA haplotypes with executive functions was analyzed in 157 clinically stable BD I patients and 210 controls. RESULTS: Allele frequencies of the rs4840463 polymorphism were significantly different between BD I patients and controls, and between patients with psychotic symptoms and controls. BD I patients performed more poorly in 11 of the 13 neurocognitive measurements compared with controls. Three MsrA haplotypes showed significant associations with different executive functions. LIMITATIONS: The limited sample size requires a cautious conclusion, and further comprehensive approaches are needed to explore the mechanism of MsrA's effect on BD I. CONCLUSIONS: The rs4840463 polymorphism in the MsrA gene may be associated with the increased risk of BD I in a Chinese population. The association of MsrA haplotypes with executive functions indicated that MsrA is associated with executive function defects in BD I patients.
Authors: Yuwen Liu; Yanyu Liang; A Ercument Cicek; Zhongshan Li; Jinchen Li; Rebecca A Muhle; Martina Krenzer; Yue Mei; Yan Wang; Nicholas Knoblauch; Jean Morrison; Siming Zhao; Yi Jiang; Evan Geller; Iuliana Ionita-Laza; Jinyu Wu; Kun Xia; James P Noonan; Zhong Sheng Sun; Xin He Journal: Am J Hum Genet Date: 2018-05-10 Impact factor: 11.025
Authors: Azmeraw T Amare; Klaus Oliver Schubert; Fasil Tekola-Ayele; Yi-Hsiang Hsu; Katrin Sangkuhl; Gregory Jenkins; Ryan M Whaley; Poulami Barman; Anthony Batzler; Russ B Altman; Volker Arolt; Jürgen Brockmöller; Chia-Hui Chen; Katharina Domschke; Daniel K Hall-Flavin; Chen-Jee Hong; Ari Illi; Yuan Ji; Olli Kampman; Toshihiko Kinoshita; Esa Leinonen; Ying-Jay Liou; Taisei Mushiroda; Shinpei Nonen; Michelle K Skime; Liewei Wang; Masaki Kato; Yu-Li Liu; Verayuth Praphanphoj; Julia C Stingl; William V Bobo; Shih-Jen Tsai; Michiaki Kubo; Teri E Klein; Richard M Weinshilboum; Joanna M Biernacka; Bernhard T Baune Journal: Front Psychiatry Date: 2018-03-06 Impact factor: 4.157