Charlotte M Nusman1, Janneke Anink2, Marieke H Otten2, Marion A J van Rossum3, Rick R van Rijn4, Mario Maas4, Lisette W A van Suijlekom-Smit2. 1. Department of Radiology, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands; Department of Paediatric Haematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands. Electronic address: c.m.nusman@amc.nl. 2. Department of Paediatrics/Paediatric Rheumatology, Sophia Children's Hospital, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands. 3. Department of Paediatric Haematology, Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands; Department of Paediatric Rheumatology, Reade Institute, Dr. Jan van Breemenstraat 2, Amsterdam, The Netherlands. 4. Department of Radiology, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands.
Abstract
OBJECTIVES: Juvenile idiopathic arthritis (JIA) affects bone mineral density (BMD). Dual-energy X-ray absorptiometry (DXA) is the most widely used technique to determine BMD. Digital X-ray radiogrammetry (DXR) is a feasible method for determination of cortical BMD on hand radiographs. This study aimed to compare DXR and DXA in the assessment of BMD in JIA patients. METHODS: Thirty-five JIA patients with available DXA and hand radiograph within the same time period were included from the Dutch Arthritis and Biologicals in Children register. Outcome measures for BMD were Bone Health Index from DXR and BMD total body, BMD lumbar spine and Bone Mineral Apparent Density from DXA. All measures were transformed to Z-scores. Correlations were assessed with Pearson correlation coefficients. RESULTS: Median age of the patients (60% female) was 11.7 years. Pearson correlation coefficient was significant for the absolute scores: 0.568-0.770 (p<0.001). No significant correlation was found between the Z-scores of DXA and DXR. CONCLUSIONS: The BMD assessment from the DXR was correlated to DXA measures in a cohort of JIA patients, although only in absolute scores. Future steps for implementation of DXR in clinical practice include evaluation of responsiveness to change, predictive value and comparison with other imaging techniques.
OBJECTIVES:Juvenile idiopathic arthritis (JIA) affects bone mineral density (BMD). Dual-energy X-ray absorptiometry (DXA) is the most widely used technique to determine BMD. Digital X-ray radiogrammetry (DXR) is a feasible method for determination of cortical BMD on hand radiographs. This study aimed to compare DXR and DXA in the assessment of BMD in JIA patients. METHODS: Thirty-five JIA patients with available DXA and hand radiograph within the same time period were included from the Dutch Arthritis and Biologicals in Children register. Outcome measures for BMD were Bone Health Index from DXR and BMD total body, BMD lumbar spine and Bone Mineral Apparent Density from DXA. All measures were transformed to Z-scores. Correlations were assessed with Pearson correlation coefficients. RESULTS: Median age of the patients (60% female) was 11.7 years. Pearson correlation coefficient was significant for the absolute scores: 0.568-0.770 (p<0.001). No significant correlation was found between the Z-scores of DXA and DXR. CONCLUSIONS: The BMD assessment from the DXR was correlated to DXA measures in a cohort of JIA patients, although only in absolute scores. Future steps for implementation of DXR in clinical practice include evaluation of responsiveness to change, predictive value and comparison with other imaging techniques.
Authors: P C E Hissink Muller; W G van Braak; D Schreurs; C M Nusman; S A Bergstra; R Hemke; D Schonenberg-Meinema; J M van den Berg; T W Kuijpers; Y Koopman-Keemink; M A J van Rossum; L W A van Suijlekom-Smit; D M C Brinkman; C F Allaart; R Ten Cate; M Maas Journal: Pediatr Rheumatol Online J Date: 2019-09-04 Impact factor: 3.054
Authors: Silvia Ciancia; Rick R van Rijn; Wolfgang Högler; Natasha M Appelman-Dijkstra; Annemieke M Boot; Theo C J Sas; Judith S Renes Journal: Eur J Pediatr Date: 2022-04-06 Impact factor: 3.860
Authors: Flora McErlane; Roberto Carrasco; Lianne Kearsley-Fleet; Eileen M Baildam; Lucy R Wedderburn; Helen E Foster; Yiannis Ioannou; S E Alice Chieng; Joyce E Davidson; Wendy Thomson; Kimme L Hyrich Journal: Semin Arthritis Rheum Date: 2017-11-07 Impact factor: 5.532