Literature DB >> 26116902

Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis.

Ganji Purnachandra Nagaraju1, Pallaval Veera Bramhachari2, Godi Raghu2, Bassel F El-Rayes3.   

Abstract

Tumor growth creates a hypoxic microenvironment, which promotes angiogenesis and aggressive tumor growth and invasion. HIF1α is a central molecule involved in mediating these effects of hypoxia. In colorectal cancer (CRC), hypoxia stabilizes the transcription factor HIF1α, leading to the expression of genes that are involved in tumor vascularization, metastasis/migration, cell survival and chemo-resistance. Therefore, HIF1α is a rational target for the development of new therapeutics for CRC. This article reviews the central role of HIF1α in CRC angiogenesis, metastasis, and progression as well as the strategies to target HIF1α stabilization.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Colorectal cancer; HIF1α; Metastasis; Stemness; Tumor resistance

Mesh：

Substances：

Year:  2015        PMID： 26116902     DOI： 10.1016/j.canlet.2015.06.005

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  42 in total

1.  Hypoxia-Inducible Factors and Cancer.

Authors:  Jonathan C Jun; Aman Rathore; Haris Younas; Daniele Gilkes; Vsevolod Y Polotsky
Journal:  Curr Sleep Med Rep       Date:  2017-01-28

Review 2.  Reciprocal regulations between miRNAs and HIF-1α in human cancers.

Authors:  Wanli Yang; Jiaojiao Ma; Wei Zhou; Bo Cao; Xin Zhou; Hongwei Zhang; Qingchuan Zhao; Liu Hong; Daiming Fan
Journal:  Cell Mol Life Sci       Date:  2018-10-13       Impact factor: 9.261

3.  Baseline [(18)F]FMISO μPET as a Predictive Biomarker for Response to HIF-1α Inhibition Combined with 5-FU Chemotherapy in a Human Colorectal Cancer Xenograft Model.

Authors:  Sven De Bruycker; Christel Vangestel; Tim Van den Wyngaert; Leonie Wyffels; An Wouters; Patrick Pauwels; Steven Staelens; Sigrid Stroobants
Journal:  Mol Imaging Biol       Date:  2016-08       Impact factor: 3.488

Review 4.  Dysregulation of TTP and HuR plays an important role in cancers.

Authors:  Hao Wang; Nannan Ding; Jian Guo; Jiazeng Xia; Yulan Ruan
Journal:  Tumour Biol       Date:  2016-09-19

5.  Bishonokiol A inhibits breast cancer cell invasion and migration by suppressing hypoxia inducible factor-1α.

Authors:  Hong-Mei Li; Jian Miao; Meilin Zhu; Meijia Gao; Yiqun Dai; Qiang Huo; Tao Ma; Cheng-Zhu Wu
Journal:  J Bioenerg Biomembr       Date:  2019-05-06       Impact factor: 2.945

6.  Does obstructive sleep apnea increase the risk of breast cancer in women during and after menopause?

Authors:  Allan Saj Porcacchia; Isabela Antunes Ishikura; Helena Hachul; Monica L Andersen; Sergio Tufik
Journal:  J Clin Sleep Med       Date:  2022-03-01       Impact factor: 4.062

7.  Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer.

Authors:  Yen-An Tang; Yu-Feng Chen; Yi Bao; Sylvia Mahara; Siti Maryam J M Yatim; Gokce Oguz; Puay Leng Lee; Min Feng; Yu Cai; Ern Yu Tan; Sau Shung Fong; Zi-Huan Yang; Ping Lan; Xiao-Jian Wu; Qiang Yu
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-11       Impact factor: 11.205

Review 8.  Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis.

Authors:  Yi-Ping Tian; Yi-Min Zhu; Xiao-Hui Sun; Mao-De Lai
Journal:  Chin Med J (Engl)       Date:  2016-07-20       Impact factor: 2.628

9.  Extracellular vesicles released from cells exposed to reactive oxygen species increase annexin A2 expression and survival of target cells exposed to the same conditions.

Authors:  Ann Kari Grindheim; Anni Vedeler
Journal:  Commun Integr Biol       Date:  2016-05-19

10.  The effect of intermittent hypoxia and fecal microbiota of OSAS on genes associated with colorectal cancer.

Authors:  Jia Gao; Hailong Cao; Qiang Zhang; Bangmao Wang
Journal:  Sleep Breath       Date:  2020-10-07       Impact factor: 2.816
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