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Literature DB >> 26116790

Metabolomics applied to the pancreatic islet.

Jessica R Gooding¹, Mette V Jensen¹, Christopher B Newgard².

Abstract

Metabolomics, the characterization of the set of small molecules in a biological system, is advancing research in multiple areas of islet biology. Measuring a breadth of metabolites simultaneously provides a broad perspective on metabolic changes as the islets respond dynamically to metabolic fuels, hormones, or environmental stressors. As a result, metabolomics has the potential to provide new mechanistic insights into islet physiology and pathophysiology. Here we summarize advances in our understanding of islet physiology and the etiologies of type-1 and type-2 diabetes gained from metabolomics studies.

Entities: CellLine Chemical Disease Gene Species

Keywords: Diabetes; Islet; Lipidomics; Metabolic flux; Metabolism; Metabolomics

Mesh：

Year: 2015 PMID： 26116790 PMCID： PMC4863644 DOI： 10.1016/j.abb.2015.06.013

Source DB: PubMed Journal: Arch Biochem Biophys ISSN： 0003-9861 Impact factor: 4.013

100 in total

Review 1. Glucolipotoxicity: fuel excess and beta-cell dysfunction.

Authors: Vincent Poitout; R Paul Robertson
Journal: Endocr Rev Date: 2007-11-29 Impact factor: 19.871

Review 2. Fatty acid signaling in the beta-cell and insulin secretion.

Authors: Christopher J Nolan; Murthy S R Madiraju; Viviane Delghingaro-Augusto; Marie-Line Peyot; Marc Prentki
Journal: Diabetes Date: 2006-12 Impact factor: 9.461

3. α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.

Authors: Shangang Zhao; Yves Mugabo; Jose Iglesias; Li Xie; Viviane Delghingaro-Augusto; Roxane Lussier; Marie-Line Peyot; Erik Joly; Bouchra Taïb; Matthew A Davis; J Mark Brown; Abdelkarim Abousalham; Herbert Gaisano; S R Murthy Madiraju; Marc Prentki
Journal: Cell Metab Date: 2014-05-08 Impact factor: 27.287

Review 4. Metabolic regulation of insulin secretion.

Authors: Kevin Keane; Philip Newsholme
Journal: Vitam Horm Date: 2014 Impact factor: 3.421

5. Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.

Authors: Sarah M Ronnebaum; Jamie W Joseph; Olga Ilkayeva; Shawn C Burgess; Danhong Lu; Thomas C Becker; A Dean Sherry; Christopher B Newgard
Journal: J Biol Chem Date: 2008-04-01 Impact factor: 5.157

6. Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

Authors: Jamie W Joseph; Matthew L Odegaard; Sarah M Ronnebaum; Shawn C Burgess; Jeffrey Muehlbauer; A Dean Sherry; Christopher B Newgard
Journal: J Biol Chem Date: 2007-09-06 Impact factor: 5.157

7. Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.

Authors: Anne Boucher; Danhong Lu; Shawn C Burgess; Sabine Telemaque-Potts; Mette V Jensen; Hindrik Mulder; May-Yun Wang; Roger H Unger; A Dean Sherry; Christopher B Newgard
Journal: J Biol Chem Date: 2004-04-07 Impact factor: 5.157

8. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.

Authors: J L Leahy; H E Cooper; D A Deal; G C Weir
Journal: J Clin Invest Date: 1986-03 Impact factor: 14.808

9. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

Authors: P Marchetti; M Bugliani; R Lupi; L Marselli; M Masini; U Boggi; F Filipponi; G C Weir; D L Eizirik; M Cnop
Journal: Diabetologia Date: 2007-09-30 Impact factor: 10.122

10. Metabolic regulation in progression to autoimmune diabetes.

Authors: Marko Sysi-Aho; Andrey Ermolov; Peddinti V Gopalacharyulu; Abhishek Tripathi; Tuulikki Seppänen-Laakso; Johanna Maukonen; Ismo Mattila; Suvi T Ruohonen; Laura Vähätalo; Laxman Yetukuri; Taina Härkönen; Erno Lindfors; Janne Nikkilä; Jorma Ilonen; Olli Simell; Maria Saarela; Mikael Knip; Samuel Kaski; Eriika Savontaus; Matej Orešič
Journal: PLoS Comput Biol Date: 2011-10-27 Impact factor: 4.475

15 in total

1. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line.

Authors: Chiara Montemurro; Suryakiran Vadrevu; Tatyana Gurlo; Alexandra E Butler; Kenny E Vongbunyong; Anton Petcherski; Orian S Shirihai; Leslie S Satin; Daniel Braas; Peter C Butler; Slavica Tudzarova
Journal: Cell Cycle Date: 2017-09-29 Impact factor: 4.534

Metabolomics applied to the pancreatic islet.

Review 1. Glucolipotoxicity: fuel excess and beta-cell dysfunction.

Review 2. Fatty acid signaling in the beta-cell and insulin secretion.

3. α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion.

Review 4. Metabolic regulation of insulin secretion.

5. Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.

6. Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

7. Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.

8. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions.

9. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

10. Metabolic regulation in progression to autoimmune diabetes.

1. Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line.

Review 2. Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell.

3. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.

Review 4. Mechanisms of the amplifying pathway of insulin secretion in the β cell.

5. Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.

Review 6. Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences.

Review 7. Precision medicine in diabetes: an opportunity for clinical translation.

8. Comprehensive Isotopic Targeted Mass Spectrometry: Reliable Metabolic Flux Analysis with Broad Coverage.

9. Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

Review 10. Metabolomics applied to islet nutrient sensing mechanisms.