Literature DB >> 26116728

A Jekyll and Hyde Profile: Type 1 Interferon Signaling Plays a Prominent Role in the Initiation and Maintenance of a Persistent Virus Infection.

Michael B A Oldstone1.   

Abstract

The hallmarks of persistent viral infections are exhaustion of virus-specific T cells, elevated production of interleukin 10 (IL-10) and programmed death-1 (PD-1) the dominant negative regulators of the immune system and disruption of secondary lymphoid tissues. Within the first 12-24 hours after mice are infected with lymphocytic choriomeningitis virus (LCMV) clone 13, which is used as a model of persistent virus infection, we note generation of high titers of type 1 interferon. Blockade of type 1 interferon significantly lessens IL-10 and PD-1/PD-L1, allows normal secondary lymphoid architecture and re-establishes antiviral T-cell function, thus eradicating the virus and clearing the infection. Hence, type 1 interferon is a master reostat for establishing persistent viral infection.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  persistent viral infection; regulation of IL-10 and PD-1/PD-L1; type 1 interferon

Mesh：

Substances：

Year:  2015        PMID： 26116728      PMCID： PMC4574552          DOI： 10.1093/infdis/jiu501

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  41 in total

Review 1.  Lymphocytic choriomeningitis virus and immunology.

Authors:  R M Zinkernagel
Journal:  Curr Top Microbiol Immunol       Date:  2002       Impact factor: 4.291

2.  Autoimmune type 1 diabetes: resolved and unresolved issues.

Authors:  A L Notkins; A Lernmark
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

Review 3.  Autoantibodies in diabetes.

Authors:  Catherine Pihoker; Lisa K Gilliam; Christiane S Hampe; Ake Lernmark
Journal:  Diabetes       Date:  2005-12       Impact factor: 9.461

4.  Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system.

Authors:  M B Oldstone; P Blount; P J Southern; P W Lampert
Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

5.  Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease.

Authors:  G A Cole; N Nathanson; R A Prendergast
Journal:  Nature       Date:  1972-08-11       Impact factor: 49.962

6.  Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Authors:  R M Zinkernagel; P C Doherty
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

7.  Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection.

Authors:  David G Brooks; Dorian B McGavern; Michael B A Oldstone
Journal:  J Clin Invest       Date:  2006-05-18       Impact factor: 14.808

8.  Restoring function in exhausted CD8 T cells during chronic viral infection.

Authors:  Daniel L Barber; E John Wherry; David Masopust; Baogong Zhu; James P Allison; Arlene H Sharpe; Gordon J Freeman; Rafi Ahmed
Journal:  Nature       Date:  2005-12-28       Impact factor: 49.962

9.  Viral immune evasion due to persistence of activated T cells without effector function.

Authors:  A J Zajac; J N Blattman; K Murali-Krishna; D J Sourdive; M Suresh; J D Altman; R Ahmed
Journal:  J Exp Med       Date:  1998-12-21       Impact factor: 14.307

10.  Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells.

Authors:  N Sevilla; S Kunz; A Holz; H Lewicki; D Homann; H Yamada; K P Campbell; J C de La Torre; M B Oldstone
Journal:  J Exp Med       Date:  2000-11-06       Impact factor: 14.307
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Journal:  JCI Insight       Date:  2016-12-08

Review 2.  Responses to Cytokines and Interferons that Depend upon JAKs and STATs.

Authors:  George R Stark; HyeonJoo Cheon; Yuxin Wang
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-01-02       Impact factor: 9.708

3.  Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection.

Authors:  Matthieu Daugan; Armstrong Murira; Barbara C Mindt; Amélie Germain; Esther Tarrab; Pascal Lapierre; Jörg H Fritz; Alain Lamarre
Journal:  Front Immunol       Date:  2016-12-05       Impact factor: 7.561

Review 4.  Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer.

Authors:  Isobel S Okoye; Michael Houghton; Lorne Tyrrell; Khaled Barakat; Shokrollah Elahi
Journal:  Front Immunol       Date:  2017-09-29       Impact factor: 7.561

5.  IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health.

Authors:  Louise A Swainson; Ashish Arunkumar Sharma; Khader Ghneim; Susan Pereira Ribeiro; Peter Wilkinson; Richard M Dunham; Rebecca G Albright; Samson Wong; Jacob D Estes; Michael Piatak; Steven G Deeks; Peter W Hunt; Rafick-Pierre Sekaly; Joseph M McCune
Journal:  JCI Insight       Date:  2022-03-08
  5 in total

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