Thomas M Berghaus1, Christian Faul2, Wolfgang von Scheidt2, Martin Schwaiblmair2. 1. Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum Augsburg, Ludwig-Maximilians-University Munich, Stenglinstrasse 2, 86156, Augsburg, Germany. thomas.berghaus@klinikum-augsburg.de. 2. Department of Cardiology, Respiratory Medicine and Intensive Care, Klinikum Augsburg, Ludwig-Maximilians-University Munich, Stenglinstrasse 2, 86156, Augsburg, Germany.
Abstract
BACKGROUND: Sleep-disordered breathing (SDB) is associated with prothrombotic effects that could lead to venous thromboembolic diseases. OBJECTIVE: The objective of this study is to clarify the prevalence of SDB among survivors of pulmonary embolism (PE). METHODS: One hundred six consecutive PE patients were prospectively evaluated by portable monitoring (PM). Nocturnal polysomnography was performed in all subjects who were diagnosed by PM to have an apnoea-hypopnoea index (AHI) > 15/h or evidence of increased daytime sleepiness. RESULTS: The overall SDB prevalence in the study population was 58.5 %. Mild obstructive sleep apnoea (OSA) was diagnosed in 35.8 % of patients. Of the subjects, 12.3 % suffered from moderate OSA. In 10.4 % of study participants, OSA was found to be severe. High-risk PE was significantly more frequent among subjects with an AHI > 15/h (p = 0.005). CONCLUSION: OSA is a common comorbidity of PE and possibly represents an additional risk factor for hemodynamic instability in PE patients.
BACKGROUND:Sleep-disordered breathing (SDB) is associated with prothrombotic effects that could lead to venous thromboembolic diseases. OBJECTIVE: The objective of this study is to clarify the prevalence of SDB among survivors of pulmonary embolism (PE). METHODS: One hundred six consecutive PE patients were prospectively evaluated by portable monitoring (PM). Nocturnal polysomnography was performed in all subjects who were diagnosed by PM to have an apnoea-hypopnoea index (AHI) > 15/h or evidence of increased daytime sleepiness. RESULTS: The overall SDB prevalence in the study population was 58.5 %. Mild obstructive sleep apnoea (OSA) was diagnosed in 35.8 % of patients. Of the subjects, 12.3 % suffered from moderate OSA. In 10.4 % of study participants, OSA was found to be severe. High-risk PE was significantly more frequent among subjects with an AHI > 15/h (p = 0.005). CONCLUSION: OSA is a common comorbidity of PE and possibly represents an additional risk factor for hemodynamic instability in PE patients.
Authors: Dinah Konnerth; Florian Schwarz; Michael Probst; Martin Seidler; Tanja Wagner; Christian Faul; Wolfgang von Scheidt; Martin Schwaiblmair; Thomas M Berghaus Journal: J Thromb Thrombolysis Date: 2018-08 Impact factor: 2.300
Authors: Fabian Geissenberger; Florian Schwarz; Michael Probst; Sabine Haberl; Asawari Parkhe; Christian Faul; Dirk von Lewinski; Thomas Kroencke; Martin Schwaiblmair; Wolfgang von Scheidt; Thomas M Berghaus Journal: Clin Res Cardiol Date: 2019-04-23 Impact factor: 5.460
Authors: Thomas M Berghaus; Fabian Geissenberger; Dinah Konnerth; Michael Probst; Thomas Kröncke; Florian Schwarz Journal: Clin Med Insights Circ Respir Pulm Med Date: 2020-12-10
Authors: Rodrigo Jiménez-García; Ana López-de-Andrés; Javier de-Miguel-Diez; Marta Lopez-Herranz; Valentín Hernandez-Barrera; David Jimenez; Manuel Monreal Journal: Sci Rep Date: 2021-09-15 Impact factor: 4.379