Xin Liu1,2, Zhiyu Chen1,2, Xiaoying Zhao1,2, Mingzhu Huang1,2, Chenchen Wang1,2, Wei Peng1,2, Jiliang Yin1,2, Jin Li1,2, Guang He2, Xin Li3, Xiaodong Zhu1,2. 1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, China. 2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 3. Bio-X Center, Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, China.
Abstract
AIM: The present study analyzed Type 2 diabetes mellitus (T2D)-related gene polymorphisms and their impacts on chemotherapeutic response and survival in patients with metastatic gastric cancer (MGC). PATIENTS & METHODS: This retrospective study enrolled 108 MGC patients treated with first-line EOF chemotherapy (epirubicin, oxaliplatin and 5-fluorouracil combination chemotherapy). Eleven single nucleotide polymorphisms of five T2D-related genes were determined. RESULTS: Among the 11 single nucleotide polymorphisms, three (IGF2BP2 rs4402960, IGF2BP2 rs6769511 and KCNQ1 rs163182) were significantly associated with disease control rate and two (GCKR rs780093 and rs780094) were significantly associated with progression-free and overall survival. CONCLUSION: Our results suggest IGF2BP2 and KCNQ1 polymorphisms might be independent predictors of chemotherapeutic response, while GCKR polymorphisms might be independent predictors of survival in MGC patients treated with first-line EOF chemotherapy. Original submitted 30 June 2014; revision submitted 15 April 2015.
AIM: The present study analyzed Type 2 diabetes mellitus (T2D)-related gene polymorphisms and their impacts on chemotherapeutic response and survival in patients with metastatic gastric cancer (MGC). PATIENTS & METHODS: This retrospective study enrolled 108 MGCpatients treated with first-line EOF chemotherapy (epirubicin, oxaliplatin and 5-fluorouracil combination chemotherapy). Eleven single nucleotide polymorphisms of five T2D-related genes were determined. RESULTS: Among the 11 single nucleotide polymorphisms, three (IGF2BP2rs4402960, IGF2BP2rs6769511 and KCNQ1rs163182) were significantly associated with disease control rate and two (GCKRrs780093 and rs780094) were significantly associated with progression-free and overall survival. CONCLUSION: Our results suggest IGF2BP2 and KCNQ1 polymorphisms might be independent predictors of chemotherapeutic response, while GCKR polymorphisms might be independent predictors of survival in MGCpatients treated with first-line EOF chemotherapy. Original submitted 30 June 2014; revision submitted 15 April 2015.
Entities:
Keywords:
GCKR; IGF2BP2; KCNQ1; biomarker; chemotherapy; gastric cancer