Radhika Patil1, Kirsti Uusi-Rasi1,2, Kari Tokola1, Saija Karinkanta1, Pekka Kannus1,3,4, Harri Sievänen1. 1. UKK Institute for Health Promotion Research, Tampere, Finland. 2. Research Department, Tampere University Hospital, Tampere, Finland. 3. Department of Trauma, Musculoskeletal Surgery and Rehabilitation, Tampere University Hospital, Tampere, Finland. 4. Medical School, University of Tampere, Tampere, Finland.
Abstract
OBJECTIVES: To investigate the effects of multimodal supervised exercise on physical functioning, falls, and related injuries in older women. DESIGN: Two-year randomized controlled trial. SETTING: Tampere, Finland. PARTICIPANTS: Women aged 70 to 80 who had fallen in the previous year (n = 409). INTERVENTION: Participants were randomly assigned to an exercise or control group (ClinicalTrial.gov NCT00986466). Exercisers participated in group exercise classes twice a week for 12 months and once a week for the subsequent 12 months and home exercises. Controls maintained their current physical activity. MEASUREMENTS: Physical functioning assessed at baseline and at 6-month intervals during the intervention. Falls and related injuries monitored with fall diaries. RESULTS: Intention-to-treat analyses showed that exercise led to significant improvements in physical functioning. Leg strength differed significantly between the groups (mean change: 14.1%, 95% confidence interval (CI) = 8.0 to 20.2 in exercisers; 1.6%, 95% CI = -4.5 to 7.7 in controls; P < .001). Chair stand time also differed significantly between groups (7.4%, 95% CI 3.8 to 10.8% in exercisers; 2.4%, 95% CI = -1.6 to 6.2) in controls; P = .02). Between-group differences were significant for fast walking speed (P = .003) and probability of completing the backward walking test (P < .001), favoring exercisers. Timed Up-and-Go and grip strength did not differ between groups. There was no difference in the total falls incidence rate ratio (IRR = 1.0, 95% CI = 0.79 to 1.26), but exercisers were less likely to have medically attended injurious falls (IRR = 0.45, 95% CI = 0.27 to 0.78; P = .004). CONCLUSION: Twenty-four months of multimodal exercise enhanced physical functioning in women aged 70 to 80 with a history of falls. Although the total number of falls was not lower than in controls, the rate of medically attended injurious falls was more than 50% lower.
RCT Entities:
OBJECTIVES: To investigate the effects of multimodal supervised exercise on physical functioning, falls, and related injuries in older women. DESIGN: Two-year randomized controlled trial. SETTING: Tampere, Finland. PARTICIPANTS: Women aged 70 to 80 who had fallen in the previous year (n = 409). INTERVENTION: Participants were randomly assigned to an exercise or control group (ClinicalTrial.gov NCT00986466). Exercisers participated in group exercise classes twice a week for 12 months and once a week for the subsequent 12 months and home exercises. Controls maintained their current physical activity. MEASUREMENTS: Physical functioning assessed at baseline and at 6-month intervals during the intervention. Falls and related injuries monitored with fall diaries. RESULTS: Intention-to-treat analyses showed that exercise led to significant improvements in physical functioning. Leg strength differed significantly between the groups (mean change: 14.1%, 95% confidence interval (CI) = 8.0 to 20.2 in exercisers; 1.6%, 95% CI = -4.5 to 7.7 in controls; P < .001). Chair stand time also differed significantly between groups (7.4%, 95% CI 3.8 to 10.8% in exercisers; 2.4%, 95% CI = -1.6 to 6.2) in controls; P = .02). Between-group differences were significant for fast walking speed (P = .003) and probability of completing the backward walking test (P < .001), favoring exercisers. Timed Up-and-Go and grip strength did not differ between groups. There was no difference in the total falls incidence rate ratio (IRR = 1.0, 95% CI = 0.79 to 1.26), but exercisers were less likely to have medically attended injurious falls (IRR = 0.45, 95% CI = 0.27 to 0.78; P = .004). CONCLUSION: Twenty-four months of multimodal exercise enhanced physical functioning in women aged 70 to 80 with a history of falls. Although the total number of falls was not lower than in controls, the rate of medically attended injurious falls was more than 50% lower.
Authors: Antonino Patti; Antonino Bianco; Bettina Karsten; Maria Alessandra Montalto; Giuseppe Battaglia; Marianna Bellafiore; Daniela Cassata; Fabio Scoppa; Antonio Paoli; Angelo Iovane; Giuseppe Messina; Antonio Palma Journal: Work Date: 2017
Authors: Neildja Maria da Silva; Monalisa Silva de França; Dellis Kariny Freitas Holanda de Almeida; Evelin Suyany Guedes de Lima; Vinícius Hugley Brito Dos Santos; João Victor de Araújo Souza; Ana Rodriguez Larrad; Débora de Almeida Aloise; Núbia Maria Freire Vieira Lima Journal: J Aging Res Date: 2021-06-03
Authors: Marcello Maggio; Gian Paolo Ceda; Andrea Ticinesi; Francesca De Vita; Giovanni Gelmini; Cosimo Costantino; Tiziana Meschi; Reto W Kressig; Matteo Cesari; Massimo Fabi; Fulvio Lauretani Journal: PLoS One Date: 2016-04-14 Impact factor: 3.240