| Literature DB >> 26114811 |
Hardeep Kaur1, Jan Balzarini2, Carmen de Kock3, Peter J Smith3, Kelly Chibale4, Kamaljit Singh5.
Abstract
A series of hybrids comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of pyrimidine displayed the highest antiplasmodial activity [IC50 = 56 nM] against the CQ(R) (Dd2) strain, which is four-fold greater than CQ.Entities:
Keywords: 4-Aminoquinoline; Antiplasmodial agents; Cytotoxic activity; Heme binding; Hybrid antimalarials; Pyrimidine
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Year: 2015 PMID： 26114811 DOI： 10.1016/j.ejmech.2015.06.024
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514