Jung Woo Lee1, Yookyung Kim2, Vidya Perera3,4, Andrew J McLachlan5,6, Kyun-Seop Bae7. 1. Department of Human Ecology, College of Education, Korea University Graduate School, Seoul, Republic of Korea. jungwooku@gmail.com. 2. Department of Human Ecology, College of Education, Korea University Graduate School, Seoul, Republic of Korea. yookyung_kim@korea.ac.kr. 3. School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA. vidyaper@buffalo.edu. 4. Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia. vidyaper@buffalo.edu. 5. Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia. Andrew.mclachlan@sydney.edu.au. 6. Center for Education and Research on Ageing, Concord Hospital, Concord, NSW, Australia. Andrew.mclachlan@sydney.edu.au. 7. Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. ksbae@amc.seoul.kr.
Abstract
The fast-growing consumption of caffeinated energy drinks (CEDs) is linked to increasing reports of caffeine intoxication in adolescents. There is limited data available regarding plasma caffeine concentrations in this population after CED intake and the potential implications for caffeine-related toxicity. This study was an in silico population pharmacokinetic analysis of caffeine. Population pharmacokinetic model of oral caffeine was derived from a previous study of healthy male volunteers. Maximal plasma caffeine concentration (C max) profiles following ingestion of one or two servings of popular CEDs were predicted using Monte Carlo simulation and available population body weight data of 10-15-year-old Korean adolescents. Caffeine C max values were positively correlated with the amount of caffeine ingested in CEDs and negatively correlated with body weight. The median (range) C max profiles varied from a low of 1.2 (0.5-2.6) mg/L to a concentration that is potentially associated with harmful caffeine-related effects of 25.4 (8.1-55.6) mg/L. A subgroup of female 10-11-year-old subjects exhibited the highest caffeine exposure profiles. CONCLUSION: These data indicate that CED ingestion can increase the risk of serious caffeine intoxication in young adolescents, particularly those with low body mass. WHAT IS KNOWN: • Excessive consumption of caffeine can lead to serious caffeine intoxication. • The risk of potential harmful caffeine intoxication after ingestion of caffeinated energy drinks (CED) has not been adequately evaluated in adolescents. WHAT IS NEW: • Predicted maximal plasma caffeine concentration profiles of adolescents with lower body weights showed an overlap with the ingested caffeine concentrations obtained from documented fatalities. • The present simulation-based pharmacokinetic analysis demonstrates that CED ingestion could lead to potentially serious caffeine intoxication in this cohort.
The fast-growing consumption of caffeinated energy drinks (CEDs) is linked to increasing reports of caffeine intoxication in adolescents. There is limited data available regarding plasma caffeine concentrations in this population after CED intake and the potential implications for caffeine-related toxicity. This study was an in silico population pharmacokinetic analysis of caffeine. Population pharmacokinetic model of oral caffeine was derived from a previous study of healthy male volunteers. Maximal plasma caffeine concentration (C max) profiles following ingestion of one or two servings of popular CEDs were predicted using Monte Carlo simulation and available population body weight data of 10-15-year-old Korean adolescents. Caffeine C max values were positively correlated with the amount of caffeine ingested in CEDs and negatively correlated with body weight. The median (range) C max profiles varied from a low of 1.2 (0.5-2.6) mg/L to a concentration that is potentially associated with harmful caffeine-related effects of 25.4 (8.1-55.6) mg/L. A subgroup of female 10-11-year-old subjects exhibited the highest caffeine exposure profiles. CONCLUSION: These data indicate that CED ingestion can increase the risk of serious caffeine intoxication in young adolescents, particularly those with low body mass. WHAT IS KNOWN: • Excessive consumption of caffeine can lead to serious caffeine intoxication. • The risk of potential harmful caffeine intoxication after ingestion of caffeinated energy drinks (CED) has not been adequately evaluated in adolescents. WHAT IS NEW: • Predicted maximal plasma caffeine concentration profiles of adolescents with lower body weights showed an overlap with the ingested caffeine concentrations obtained from documented fatalities. • The present simulation-based pharmacokinetic analysis demonstrates that CED ingestion could lead to potentially serious caffeine intoxication in this cohort.
Entities:
Keywords:
Adolescent; Caffeine; Energy drink; Monte Carlo method
Authors: Sara M Seifert; Steven A Seifert; Judy L Schaechter; Alvin C Bronstein; Blaine E Benson; Eugene R Hershorin; Kristopher L Arheart; Vivian I Franco; Steven E Lipshultz Journal: Clin Toxicol (Phila) Date: 2013-08 Impact factor: 4.467
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