Literature DB >> 26112314

Treatment of traumatic brain injury with anti-inflammatory drugs.

Peter J Bergold1.   

Abstract

Traumatic brain injury rapidly induces inflammation. This inflammation is produced both by endogenous brain cells and circulating inflammatory cells that enter from the brain. Together they drive the inflammatory response through a wide variety of bioactive lipids, cytokines and chemokines. A large number of drugs with anti-inflammatory action have been tested in both preclinical studies and in clinical trials. These drugs either have known anti-inflammatory action or inhibit the inflammatory response through unknown mechanisms. The results of these preclinical studies and clinical trials are reviewed. Recommendations are suggested on how to improve preclinical testing of drugs to make them more relevant to evaluate for clinical trials.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Brain function; Clinical trials; Histology; Inflammatory mediators; Preclinical testing

Mesh：

Substances：

Year:  2015        PMID： 26112314      PMCID： PMC6007860          DOI： 10.1016/j.expneurol.2015.05.024

Source DB:  PubMed          Journal:  Exp Neurol        ISSN： 0014-4886            Impact factor:   5.330


  134 in total

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