| Literature DB >> 2611213 |
S B Levery1, E D Nudelman, M E Salyan, S Hakomori.
Abstract
A series of highly polar neolacto series (poly-N-acetyllactosaminyl) gangliosides were isolated from human placenta tissue and purified by HPLC and preparative HPTLC. Two of these ganglioside fractions (G-12 and G-13) were analyzed by 500-MHz 1H NMR spectroscopy, GC-EIMS, +FAB-MS, and sequential exoglycosidase treatments. Their structures have been identified as being of the repeating N-acetyllactosamine type, multiply branched through GlcNAc beta 1----6/3 linkages, with every nonreducing Gal terminal alpha 2----3-sialosylated, as shown below. These are among the highest molecular weight glycosphingolipids whose detailed oligosaccharide structures are presently known. (formula; see text).Entities:
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Year: 1989 PMID： 2611213 DOI： 10.1021/bi00445a037
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162