Edwina H Yeung1, Alexander C McLain1,2, Nancy Anderson3, David Lawrence3, Nansi S Boghossian1,2, Charlotte Druschel4, Erin Bell5,6. 1. Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD. 2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, Columbia, SC. 3. Laboratory of Immunology, Wadsworth Center, Center for Medical Science, Albany, NY. 4. Bureau of Environmental and Occupational Epidemiology, Center for Environmental Health, New York State Department of Health, Albany, NY. 5. Department of Environmental Health Sciences, University at Albany School of Public Health, Albany, NY. 6. Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Albany, NY.
Abstract
BACKGROUND: Adipokines can serve as a measure of adipose tissue activity. Although birthweight correlates with neonatal adiposity, findings for cord blood levels of adipokines and birth outcomes have been conflicted. Therefore, we determined the cross-sectional associations between adipokines measured in newborn dried blood spots (DBS) and birth outcomes. METHODS: The Upstate KIDS study enrolled mothers and infants from 2008 to 2010. Among infants whose parents consented to the use of residual DBS from newborn screening, 2397 singletons and 1240 twins had adipokine measurements from the Human Obesity Panel (R&D Systems) by Luminex. Odds ratios were estimated by multivariable logistic regression for risk of birth outcomes of preterm delivery (<37 weeks for singletons, <32 for twins) and small-for-gestational age (SGA <10th for singletons and <3rd for twins age- and sex-specific percentiles) by adipokine quintiles. Generalised estimating equations were applied to account for correlations between twins. RESULTS: Singletons in the lowest compared with the highest quintile of adiponectin were more likely preterm (adjusted odds ratio 3.26; 95% confidence interval [CI] 1.99, 5.34) and SGA (1.81; [95% CI 1.18, 2.77]). Similar associations were observed among twins. Resistin was associated with preterm birth (Q1 vs. Q5: 2.08; [95% CI 1.20, 3.62]) only among singletons. Adipsin had inconsistent associations after adjustment. CONCLUSIONS: This large population-based study demonstrates that newborn DBS-measured adipokines are associated with birth outcomes, particularly preterm birth and SGA among those with lower adiponectin levels regardless of plurality.
BACKGROUND: Adipokines can serve as a measure of adipose tissue activity. Although birthweight correlates with neonatal adiposity, findings for cord blood levels of adipokines and birth outcomes have been conflicted. Therefore, we determined the cross-sectional associations between adipokines measured in newborn dried blood spots (DBS) and birth outcomes. METHODS: The Upstate KIDS study enrolled mothers and infants from 2008 to 2010. Among infants whose parents consented to the use of residual DBS from newborn screening, 2397 singletons and 1240 twins had adipokine measurements from the HumanObesity Panel (R&D Systems) by Luminex. Odds ratios were estimated by multivariable logistic regression for risk of birth outcomes of preterm delivery (<37 weeks for singletons, <32 for twins) and small-for-gestational age (SGA <10th for singletons and <3rd for twins age- and sex-specific percentiles) by adipokine quintiles. Generalised estimating equations were applied to account for correlations between twins. RESULTS: Singletons in the lowest compared with the highest quintile of adiponectin were more likely preterm (adjusted odds ratio 3.26; 95% confidence interval [CI] 1.99, 5.34) and SGA (1.81; [95% CI 1.18, 2.77]). Similar associations were observed among twins. Resistin was associated with preterm birth (Q1 vs. Q5: 2.08; [95% CI 1.20, 3.62]) only among singletons. Adipsin had inconsistent associations after adjustment. CONCLUSIONS: This large population-based study demonstrates that newborn DBS-measured adipokines are associated with birth outcomes, particularly preterm birth and SGA among those with lower adiponectin levels regardless of plurality.
Authors: Nancy J Andersen; Tapan Kumar Mondal; Mark T Preissler; Brian M Freed; Sabine Stockinger; Erin Bell; Charlotte Druschel; Germaine M Buck Louis; David A Lawrence Journal: J Immunol Methods Date: 2013-12-13 Impact factor: 2.303
Authors: Lauren K Meyer; Theodore P Ciaraldi; Robert R Henry; Alan C Wittgrove; Susan A Phillips Journal: Adipocyte Date: 2013-05-07 Impact factor: 4.534
Authors: Ramkripa Raghavan; M Daniele Fallin; Xiumei Hong; Guoying Wang; Yuelong Ji; Elizabeth A Stuart; David Paige; Xiaobin Wang Journal: J Autism Dev Disord Date: 2019-01
Authors: Nikhita Chahal; Alexander C McLain; Akhgar Ghassabian; Kara A Michels; Erin M Bell; David A Lawrence; Edwina H Yeung Journal: Nicotine Tob Res Date: 2017-07-01 Impact factor: 4.244
Authors: Elin W Blakstad; Sissel J Moltu; Britt Nakstad; Marit B Veierød; Kenneth Strømmen; Pétur B Júlíusson; Astrid N Almaas; Arild E Rønnestad; Kristin Brække; Christian A Drevon; Per O Iversen Journal: Food Nutr Res Date: 2016-12-01 Impact factor: 3.894
Authors: Sonia L Robinson; Xuehuo Zeng; Weihua Guan; Rajeshwari Sundaram; Pauline Mendola; Diane L Putnick; Robert A Waterland; Chathura J Gunasekara; Kurunthachalam Kannan; Chongjing Gao; Erin M Bell; Edwina H Yeung Journal: Environ Res Date: 2020-12-30 Impact factor: 6.498
Authors: Edwina H Yeung; Germaine Buck Louis; David Lawrence; Kurunthachalam Kannan; Alexander C McLain; Michele Caggana; Charlotte Druschel; Erin Bell Journal: BMC Med Res Methodol Date: 2016-02-04 Impact factor: 4.615