Literature DB >> 26110985

Topical haemoglobin spray for diabetic foot ulceration.

Sharon Dawn Bateman1.   

Abstract

UNLABELLED: The development and subsequent deterioration of diabetic foot ulceration (DFU) is a common occurrence across all healthcare divides, concerning all patient groups, age, gender and social environments. It increases demand on clinical resources and creates unnecessary hardship for patients. Chronic DFU is challenging to prevent and notoriously difficult to manage owing to the complex nature of the patient and the disease itself. The improvement of oxygenation to many chronic wound groups is gaining momentum across wound care; particularly in those wounds such as DFU that present with circulatory, oxygen-deficient scenarios.
METHOD: A descriptive evaluation was undertaken in an acute clinical setting where a spray solution containing purified haemoglobin was used in a cohort of 20 patients who presented with chronic (>12 weeks) DFU. Standard wound care was undertaken by 18 health professionals with no changes to products, devices or practice before evaluation. All wounds received the addition of the product on eight set occasions over a 4-week period and the resulting data correlated in regards to the set outcomes of wound surface area reduction, ease of use, adverse events and patient acceptability.
RESULTS: At 4 weeks all wounds had demonstrated positive wound reduction, there were no adverse events, all patients and clinicians found the product acceptable and easy to use. Interestingly, although not a set outcome, all wounds commenced the evaluation with wound-bed slough present and at 4 weeks 100% were deemed slough free. At a further 4-week review no patients wounds had regressed.
CONCLUSION: The incorporation of a haemoglobin spray solution within this cohort of DFU resulted in a positive improvement in wound healing and slough elimination. Further work in this area is recommended to increase the evidence.

Entities:  

Keywords:  Diabetes; Diabetic foot; Foot ulcer; Topical oxygen therapy; Wound healing

Mesh:

Substances:

Year:  2015        PMID: 26110985     DOI: 10.12968/bjon.2015.24.Sup12.S24

Source DB:  PubMed          Journal:  Br J Nurs        ISSN: 0966-0461


  3 in total

1.  Systematic review of the efficacy of topical haemoglobin therapy for wound healing.

Authors:  Jieman Hu; Shaoning Guo; Haiyan Hu; Jianan Sun
Journal:  Int Wound J       Date:  2020-05-19       Impact factor: 3.315

2.  Clinical effectiveness of hemoglobin spray (Granulox®) as adjunctive therapy in the treatment of chronic diabetic foot ulcers.

Authors:  Sharon D Hunt; Fredrik Elg
Journal:  Diabet Foot Ankle       Date:  2016-11-07

3.  Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Authors:  Alexandra Igrunkova; Alexey Fayzullin; Semyon Churbanov; Polina Shevchenko; Natalia Serejnikova; Natalia Chepelova; Dmitry Pahomov; Ekaterina Blinova; Karen Mikaelyan; Victoria Zaborova; Konstantin Gurevich; Aleksandr Urakov; Anatoly Vanin; Peter Timashev; Anatoly Shekhter
Journal:  Drug Des Devel Ther       Date:  2022-02-16       Impact factor: 4.162

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.