Anna Sala-Cunill1, Victoria Cardona. 1. aAllergy Section, Department of Internal Medicine, Hospital Universitari Vall d'Hebron bAllergy Research Unit, Allergy Department, Institut de Recerca Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain.
Abstract
PURPOSE OF REVIEW: The purpose of this study is to describe the current knowledge regarding mediators involved in anaphylactic reactions, with a special focus on key effector cells and mechanisms. RECENT FINDINGS: New insight into the potential relevance of pathways other than mast cell degranulation has been unravelled, such as the role of cytokines, platelet activation factor, lipid mediators and their metabolism or the activation of the contact system. SUMMARY: Gaining knowledge into these pathophysiologic mechanisms will allow researchers to pursue the identification of risk factors and new preventive and therapeutic strategies in anaphylaxis.
PURPOSE OF REVIEW: The purpose of this study is to describe the current knowledge regarding mediators involved in anaphylactic reactions, with a special focus on key effector cells and mechanisms. RECENT FINDINGS: New insight into the potential relevance of pathways other than mast cell degranulation has been unravelled, such as the role of cytokines, platelet activation factor, lipid mediators and their metabolism or the activation of the contact system. SUMMARY: Gaining knowledge into these pathophysiologic mechanisms will allow researchers to pursue the identification of risk factors and new preventive and therapeutic strategies in anaphylaxis.
Authors: Leticia de Las Vecillas Sánchez; Leila A Alenazy; Marlene Garcia-Neuer; Mariana C Castells Journal: Int J Mol Sci Date: 2017-06-20 Impact factor: 5.923
Authors: Chandima Jeewandara; Laksiri Gomes; Sukhitha Udari; S A Paranavitane; N L A Shyamali; Graham S Ogg; Gathsaurie Neelika Malavige Journal: Immun Inflamm Dis Date: 2016-12-11