Ana Margarida Pereira1,2,3, Mário Morais-Almeida1,4, Natacha Santos1,5, Carlos Nunes4,6, Jean Bousquet7, João Almeida Fonseca2,3,4,8. 1. Immunoallergy Department, CUF-Descobertas Hospital, Lisbon, Portugal. 2. Health Information and Decision Sciences Department, Faculty of Medicine of the University of Porto, Porto, Portugal. 3. Allergy Unit, CUF-Porto Hospital & Institute, Porto, Portugal. 4. Portuguese Society of Allergy and Clinical Immunology, Sociedade Portuguesa de Alergologia e Imunologia Clínica (SPAIC), Lisbon, Portugal. 5. Allergy and Clinical Immunology Department, Centro Hospitalar S. João E.P.E., Porto, Portugal. 6. Algarve Immunoallergy Center, Portimão, Portugal. 7. Department of Allergy and Respiratory Diseases, University Hospital and INSERM, Montpellier, France. 8. CINTESIS - Center for Research in Health Technologies and Information Systems, Porto, Portugal.
Abstract
BACKGROUND: In preschool children, no study assessed the relation between wheezing and rhinitis severity. Our aims were to estimate the prevalence of current wheezing (CW) in preschoolers and to study the association between CW and current rhinitis (CR), considering its severity/persistency. METHODS: This is a cross-sectional, nationwide, population-based study including a representative sample of 5003 Portuguese children aged 3-5 years. Data were collected by a face-to-face interview with caregivers using an adapted ISAAC questionnaire. CW was defined as presence of ≥1 wheezing episode in the previous 12 months. Rhinitis severity/persistency was classified according to Allergic Rhinitis and its Impact on Asthma. RESULTS: Current wheezing prevalence was 24.5% [95% CI 23.3-25.7]; 9.4% of the participants had ≥4 wheezing episodes in the previous year. Children with CR had an odds ratio (OR) of 4.0 [95% CI 3.4-4.5] for CW; it was highest for children with moderate-severe persistent rhinitis (11.5 [95% CI 8.1-16.3]), even after adjusting for possible confounders. Wheezers with CR reported more wheezing treatment use (p = 0.024) than those without CR. There was a trend for a higher number of wheezing episodes with more persistent and severe nasal disease - 48.4% of children with moderate-severe persistent rhinitis had >4 wheezing episodes vs. 28.9% in moderate-severe intermittent, 20.0% in mild persistent, 10.8% in mild intermittent, and 3.6% in those without CR; p < 0.001. CONCLUSIONS: Current wheezing was present in almost 25% of preschool children and was strongly associated with rhinitis, especially moderate-severe persistent disease. Preschoolers with both CW and rhinitis seem to have a more severe phenotype, emphasizing the need for concurrent evaluation of nasal and bronchial symptoms even in small children.
BACKGROUND: In preschool children, no study assessed the relation between wheezing and rhinitis severity. Our aims were to estimate the prevalence of current wheezing (CW) in preschoolers and to study the association between CW and current rhinitis (CR), considering its severity/persistency. METHODS: This is a cross-sectional, nationwide, population-based study including a representative sample of 5003 Portuguese children aged 3-5 years. Data were collected by a face-to-face interview with caregivers using an adapted ISAAC questionnaire. CW was defined as presence of ≥1 wheezing episode in the previous 12 months. Rhinitis severity/persistency was classified according to Allergic Rhinitis and its Impact on Asthma. RESULTS: Current wheezing prevalence was 24.5% [95% CI 23.3-25.7]; 9.4% of the participants had ≥4 wheezing episodes in the previous year. Children with CR had an odds ratio (OR) of 4.0 [95% CI 3.4-4.5] for CW; it was highest for children with moderate-severe persistent rhinitis (11.5 [95% CI 8.1-16.3]), even after adjusting for possible confounders. Wheezers with CR reported more wheezing treatment use (p = 0.024) than those without CR. There was a trend for a higher number of wheezing episodes with more persistent and severe nasal disease - 48.4% of children with moderate-severe persistent rhinitis had >4 wheezing episodes vs. 28.9% in moderate-severe intermittent, 20.0% in mild persistent, 10.8% in mild intermittent, and 3.6% in those without CR; p < 0.001. CONCLUSIONS: Current wheezing was present in almost 25% of preschool children and was strongly associated with rhinitis, especially moderate-severe persistent disease. Preschoolers with both CW and rhinitis seem to have a more severe phenotype, emphasizing the need for concurrent evaluation of nasal and bronchial symptoms even in small children.
Authors: Maria Luz Garcia-Garcia; Cristina Calvo; Sara Ruiz; Francisco Pozo; Victoria Del Pozo; Laura Remedios; Nadia Exposito; Ana Tellez; Inmaculada Casas Journal: PLoS One Date: 2017-12-05 Impact factor: 3.240
Authors: Sungsu Jung; So Yeon Lee; Jisun Yoon; Hyun Ju Cho; Young Ho Kim; Dong In Suh; Song I Yang; Ji Won Kwon; Gwang Cheon Jang; Yong Han Sun; Sung Il Woo; You Sook Youn; Kang Seo Park; Eun Lee; Hwa Jin Cho; Myung Hee Kook; Hye Ryoung Yi; Hai Lee Chung; Ja Hyeong Kim; Hyung Young Kim; Jin A Jung; Hyang Ok Woo; Jeom Kyu Lee; Woo Sung Chang; Nam Hee Do; Hyejoo Cho; Soo Jong Hong Journal: Allergy Asthma Immunol Res Date: 2020-01 Impact factor: 5.764