CONTEXT: Mycobacterium tuberculosis (MTB) infection is rarely seen in cystic fibrosis (CF) patients. CASE REPORT: We report a 24-year-old CF patient with fever, cough, hemoptysis, and weight loss of 1week duration prior to admission. Past sputum cultures grew methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The patient was treated with broad spectrum antibiotics based on previous culture data, but failed to improve. Chest radiograph and computed tomography (CT) chest revealed chronic collapse of the anterior subsegment of right upper lobe and multiple bilateral cavitary lesions which were worse compared to prior films. MTB was suspected and was confirmed by positive acid-fast bacilli (AFB) smears and cultures. After receiving first-line antituberculous drugs, the patient's condition markedly improved. CONCLUSION: MTB is an infrequent finding, but considered a potential pathogen in CF patients, and may lead to serious pulmonary complications if there is a delay in diagnosis and treatment.
CONTEXT: Mycobacterium tuberculosis (MTB) infection is rarely seen in cystic fibrosis (CF) patients. CASE REPORT: We report a 24-year-old CFpatient with fever, cough, hemoptysis, and weight loss of 1week duration prior to admission. Past sputum cultures grew methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The patient was treated with broad spectrum antibiotics based on previous culture data, but failed to improve. Chest radiograph and computed tomography (CT) chest revealed chronic collapse of the anterior subsegment of right upper lobe and multiple bilateral cavitary lesions which were worse compared to prior films. MTB was suspected and was confirmed by positive acid-fast bacilli (AFB) smears and cultures. After receiving first-line antituberculous drugs, the patient's condition markedly improved. CONCLUSION:MTB is an infrequent finding, but considered a potential pathogen in CFpatients, and may lead to serious pulmonary complications if there is a delay in diagnosis and treatment.
Authors: Philip Onyebujoh; Alimuddin Zumla; Isabella Ribeiro; Roxana Rustomjee; Peter Mwaba; Melba Gomes; John M Grange Journal: Bull World Health Organ Date: 2005-11-10 Impact factor: 9.408
Authors: Rosa M Girón; Luis Máiz; Isabel Barrio; M Teresa Martínez; Antonio Salcedo; Concepción Prados Journal: Arch Bronconeumol Date: 2008-12 Impact factor: 4.872
Authors: Anna Berzkalns; Joseph Bates; Wen Ye; Leonard Mukasa; Anne Marie France; Naveen Patil; Zhenhua Yang Journal: PLoS One Date: 2014-03-11 Impact factor: 3.240
Authors: Asween Marco; Maria Theresa Montales; Penchala Mittadodla; Leonard Mukasa; Nutan Bhaskar; Joseph Bates; Naveen Patil Journal: Respir Med Case Rep Date: 2015-04-23