Ioanna A Comstock1, Sun Kim2, Barry Behr3, Ruth B Lathi4. 1. Obstetrics and Gynecology-Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, 900 Welch Rd Ste 350 MC 5800, Palo Alto, CA, 94304, USA. icomstoc@stanford.edu. 2. Medical Endocrinology, Stanford Hospital and Clinics, 300 Pasteur Dr S025 MC 5103, Palo Alto, CA, 94304, USA. sunhkim@stanford.edu. 3. Obstetrics and Gynecology-Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, 900 Welch Rd Ste 350 MC 5800, Palo Alto, CA, 94304, USA. behr@stanford.edu. 4. Obstetrics and Gynecology-Reproductive Endocrinology and Infertility, Stanford Hospital and Clinics, 900 Welch Rd Ste 350 MC 5800, Palo Alto, CA, 94304, USA. rlathi@stanford.edu.
Abstract
PURPOSE: The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. METHODS: This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had ≥6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of ≥5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. RESULTS: The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obese patients (57.2 versus 43.6 %, p < 0.007). There was no difference in blastocyst formation between the patients with a BMI 25-29.9 kg/m(2) with metabolic dysfunction and those with a BMI ≥30 kg/m(2). CONCLUSION: The maternal metabolic environment has a significant impact on embryo quality as measured by blastocyst formation. A decreased blastocyst formation rate is likely a significant contributor to poorer reproductive outcomes in overweight and obese women with infertility.
PURPOSE: The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. METHODS: This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had ≥6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of ≥5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. RESULTS: The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obesepatients (57.2 versus 43.6 %, p < 0.007). There was no difference in blastocyst formation between the patients with a BMI 25-29.9 kg/m(2) with metabolic dysfunction and those with a BMI ≥30 kg/m(2). CONCLUSION: The maternal metabolic environment has a significant impact on embryo quality as measured by blastocyst formation. A decreased blastocyst formation rate is likely a significant contributor to poorer reproductive outcomes in overweight and obesewomen with infertility.
Authors: A M E Lintsen; P C M Pasker-de Jong; E J de Boer; C W Burger; C A M Jansen; D D M Braat; F E van Leeuwen Journal: Hum Reprod Date: 2005-04-07 Impact factor: 6.918
Authors: Emily S Jungheim; Erica L Schoeller; Kerri L Marquard; Erica D Louden; Jean E Schaffer; Kelle H Moley Journal: Endocrinology Date: 2010-06-23 Impact factor: 4.736
Authors: Divya K Shah; Stacey A Missmer; Katharine F Berry; Catherine Racowsky; Elizabeth S Ginsburg Journal: Obstet Gynecol Date: 2011-07 Impact factor: 7.661
Authors: Douglas T Carrell; Kirtly P Jones; C Matthew Peterson; Vincent Aoki; Benjamin R Emery; Bruce R Campbell Journal: Reprod Biomed Online Date: 2001 Impact factor: 3.828
Authors: Rashmi Kudesia; Hongyu Wu; Karen Hunter Cohn; Lei Tan; Joseph A Lee; Alan B Copperman; Piraye Yurttas Beim Journal: J Assist Reprod Genet Date: 2018-08-21 Impact factor: 3.412
Authors: Esther B Baart; Régine P M Steegers-Theunissen; Linette van Duijn; Melek Rousian; Jeffrey Hoek; Sten P Willemsen; Eva S van Marion; Joop S E Laven Journal: Reprod Biol Endocrinol Date: 2021-09-18 Impact factor: 5.211