| Literature DB >> 26109297 |
Pierre Edouard Bougis1, Marie-France Martin-Eauclaire2.
Abstract
Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins.Entities:
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Year: 2015 PMID： 26109297
Source DB: PubMed Journal: Sheng Li Xue Bao ISSN： 0371-0874