Literature DB >> 26108709

A Review of the Toxicologic Implications of Obesity.

Matthew Zuckerman1, Howard A Greller, Kavita M Babu.   

Abstract

The increasing prevalence of obesity in developed nations has far-reaching implications for medical toxicology. The management of obese patients is complicated by comorbid illnesses, changes in cardiovascular and respiratory physiology, alterations in pharmacokinetics, and a lack of studies to identify appropriate dosing for current therapeutics and antidotes. In this review article, we examine obesity-associated physiologic and pharmacokinetic changes that may increase the vulnerability of obese patients to overdose. Further research is needed to characterize the relationship between drug toxicity and obesity.

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Year:  2015        PMID： 26108709      PMCID： PMC4547963          DOI： 10.1007/s13181-015-0488-6

Source DB:  PubMed          Journal:  J Med Toxicol        ISSN： 1556-9039


  124 in total

Review 1.  A systematic review of drug absorption following bariatric surgery and its theoretical implications.

Authors:  R Padwal; D Brocks; A M Sharma
Journal:  Obes Rev       Date:  2009-06-02       Impact factor: 9.213

Review 2.  Pharmacokinetic considerations in obesity.

Authors:  R A Blouin; G W Warren
Journal:  J Pharm Sci       Date:  1999-01       Impact factor: 3.534

3.  Obesity and severe obesity forecasts through 2030.

Authors:  Eric A Finkelstein; Olga A Khavjou; Hope Thompson; Justin G Trogdon; Liping Pan; Bettylou Sherry; William Dietz
Journal:  Am J Prev Med       Date:  2012-06       Impact factor: 5.043

4.  Charcoal peritonitis causing chronic pelvic pain: a unique complication following bariatric surgery.

Authors:  Kyle Dunning; Matthew R Plymyer
Journal:  Obes Surg       Date:  2006-09       Impact factor: 4.129

5.  Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults.

Authors:  Eugenia E Calle; Carmen Rodriguez; Kimberly Walker-Thurmond; Michael J Thun
Journal:  N Engl J Med       Date:  2003-04-24       Impact factor: 91.245

Review 6.  The SEEKING mind: primal neuro-affective substrates for appetitive incentive states and their pathological dynamics in addictions and depression.

Authors:  Antonio Alcaro; Jaak Panksepp
Journal:  Neurosci Biobehav Rev       Date:  2011-03-15       Impact factor: 8.989

Review 7.  Structural renal changes in obesity and diabetes.

Authors:  Kerstin Amann; Kerstin Benz
Journal:  Semin Nephrol       Date:  2013-01       Impact factor: 5.299

8.  Therapeutic drug monitoring of vancomycin in a morbidly obese patient.

Authors:  S R Penzak; P O Gubbins; K A Rodvold; S L Hickerson
Journal:  Ther Drug Monit       Date:  1998-06       Impact factor: 3.681

Review 9.  Pharmacology of morphine in obese patients: clinical implications.

Authors:  Célia Lloret Linares; Xavier Declèves; Jean Michel Oppert; Arnaud Basdevant; Karine Clement; Christophe Bardin; Jean Michel Scherrmann; Jean Pierre Lepine; Jean François Bergmann; Stéphane Mouly
Journal:  Clin Pharmacokinet       Date:  2009       Impact factor: 6.447

10.  Impact of obesity on the bioavailability of peginterferon-α2a and ribavirin and treatment outcome for chronic hepatitis C genotype 2 or 3.

Authors:  Åsa Alsiö; Karolina Rembeck; Galia Askarieh; Peer Brehm Christensen; Martti Färkkilä; Nina Langeland; Mads Rauning Buhl; Court Pedersen; Kristine Mørch; Bart L Haagmans; Salmir Nasic; Johan Westin; Kristoffer Hellstrand; Gunnar Norkrans; Martin Lagging
Journal:  PLoS One       Date:  2012-05-24       Impact factor: 3.240
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  8 in total

Review 1.  Considerations for dosing immunoglobulin in obese patients.

Authors:  J P Hodkinson
Journal:  Clin Exp Immunol       Date:  2017-04-17       Impact factor: 4.330

Review 2.  Hypertension in Obesity and the Impact of Weight Loss.

Authors:  Jordana B Cohen
Journal:  Curr Cardiol Rep       Date:  2017-08-24       Impact factor: 2.931

3.  Higher chlorzoxazone clearance in obese children compared with nonobese peers.

Authors:  C Gade; K Dalhoff; T S Petersen; T Riis; C Schmeltz; E Chabanova; H R Christensen; G Mikus; J Burhenne; J C Holm; H Holst
Journal:  Br J Clin Pharmacol       Date:  2018-06-03       Impact factor: 4.335

Review 4.  Overfed but undernourished: recognizing nutritional inadequacies/deficiencies in patients with overweight or obesity.

Authors:  Arne Astrup; Susanne Bügel
Journal:  Int J Obes (Lond)       Date:  2018-07-06       Impact factor: 5.095

Review 5.  Peri-operative Medication Dosing in Adult Obese Elective Surgical Patients: A Systematic Review of Clinical Studies.

Authors:  Zahid Hussain; Colin Curtain; Corinne Mirkazemi; Syed Tabish Razi Zaidi
Journal:  Clin Drug Investig       Date:  2018-08       Impact factor: 2.859

6.  ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy.

Authors:  Sergio D Bergese; Marek Brzezinski; Gregory B Hammer; Timothy L Beard; Peter H Pan; Sharon E Mace; Richard D Berkowitz; Kristina Cochrane; Linda Wase; Harold S Minkowitz; Ashraf S Habib
Journal:  J Pain Res       Date:  2019-11-14       Impact factor: 3.133

Review 7.  Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.

Authors:  Julie Massart; Karima Begriche; Anne Corlu; Bernard Fromenty
Journal:  Int J Mol Sci       Date:  2022-01-19       Impact factor: 5.923

Review 8.  Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?

Authors:  Pierre-Jean Ferron; Thomas Gicquel; Bruno Mégarbane; Bruno Clément; Bernard Fromenty
Journal:  Biochimie       Date:  2020-09-03       Impact factor: 4.079
  8 in total

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