PURPOSE: This retrospective analysis evaluated the outcome of patients with spinal bone metastases of renal cell cancer after radiotherapy (RT) in terms of stability and survival, using a validated scoring system for spinal stability assessment. MATERIALS AND METHODS: The survival rates of 155 patients with bone metastases of renal cancer treated from January 2000 to January 2012 were determined. The stability of irradiated osteolytic lesions of the thoracic and lumbar spine was evaluated retrospectively using the Taneichi score and analyzed for predictive factors. The effects of therapy in terms of changes in neurological signs and tumor-related pain were recorded. RESULTS: Follow-up with regular computed tomography (CT) was available for 28 patients, 14 with unstable metastases. One hundred thiry-two patients (85%) died during follow-up. RT could not improve the stability of vertebral bodies after 3 and 6 months. Consequently, none of the examined predictive factors such as age, number of bone metastases and systemic therapy showed a significant correlation with stability 6 months after RT. The median survival of all 155 patients after diagnosis of bone metastases was 12.9 months. Improvement of pain and neurological deficits occurred in 60%, and in 24% of the respective affected in all patients. CONCLUSIONS: RT was unable to improve the stability of vertebral metastases, probably due to the short overall survival, which resulted in an insufficient number of patients with evaluable follow-up. RT allowed reduction of pain and neurological deficits. A short fractionation schedule may be preferred in this situation.
PURPOSE: This retrospective analysis evaluated the outcome of patients with spinal bone metastases of renal cell cancer after radiotherapy (RT) in terms of stability and survival, using a validated scoring system for spinal stability assessment. MATERIALS AND METHODS: The survival rates of 155 patients with bone metastases of renal cancer treated from January 2000 to January 2012 were determined. The stability of irradiated osteolytic lesions of the thoracic and lumbar spine was evaluated retrospectively using the Taneichi score and analyzed for predictive factors. The effects of therapy in terms of changes in neurological signs and tumor-related pain were recorded. RESULTS: Follow-up with regular computed tomography (CT) was available for 28 patients, 14 with unstable metastases. One hundred thiry-two patients (85%) died during follow-up. RT could not improve the stability of vertebral bodies after 3 and 6 months. Consequently, none of the examined predictive factors such as age, number of bone metastases and systemic therapy showed a significant correlation with stability 6 months after RT. The median survival of all 155 patients after diagnosis of bone metastases was 12.9 months. Improvement of pain and neurological deficits occurred in 60%, and in 24% of the respective affected in all patients. CONCLUSIONS: RT was unable to improve the stability of vertebral metastases, probably due to the short overall survival, which resulted in an insufficient number of patients with evaluable follow-up. RT allowed reduction of pain and neurological deficits. A short fractionation schedule may be preferred in this situation.
Authors: Tilman Bostel; Robert Förster; Ingmar Schlampp; Tania Sprave; Thomas Bruckner; Nils Henrik Nicolay; Stefan Ezechiel Welte; Jürgen Debus; Harald Rief Journal: Radiat Oncol Date: 2017-07-11 Impact factor: 3.481
Authors: Eva Meyerhof; Tanja Sprave; Stefan Ezechiel Welte; Nils H Nicolay; Robert Förster; Tilman Bostel; Thomas Bruckner; Ingmar Schlampp; Jürgen Debus; Harald Rief Journal: Trials Date: 2017-03-03 Impact factor: 2.279
Authors: Tilman Bostel; Robert Förster; Ingmar Schlampp; Tanja Sprave; Sati Akbaba; Daniel Wollschläger; Jürgen Debus; Arnulf Mayer; Heinz Schmidberger; Harald Rief; Nils Henrik Nicolay Journal: Strahlenther Onkol Date: 2019-06-25 Impact factor: 3.621
Authors: Tilman Bostel; Sati Akbaba; Daniel Wollschläger; Tristan Klodt; Laura Oebel; Arnulf Mayer; Sophia Drabke; Tanja Sprave; Jürgen Debus; Robert Förster; Harald Rief; Alexander Rühle; Anca-Ligia Grosu; Heinz Schmidberger; Nils H Nicolay Journal: Front Oncol Date: 2021-10-19 Impact factor: 6.244