Burak Kaya1, Cem Çerkez1, Servet Elçin Işılgan1, Hilal Göktürk2, Zeynep Yığman3, Savaş Serel1, Belgin Can3, Hakan Ergün4. 1. a 1 Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara University School of Medicine , Ankara, Turkey. 2. b 2 Department of Histology and Embryology, Yıldırım Beyazıt University School of Medicine , Ankara, Turkey. 3. c 3 Department of Histology and Embryology. 4. d 4 Department of Medical Pharmacology, Ankara University School of Medicine , Ankara, Turkey.
Abstract
OBJECTIVE: The most important issue in flap surgery is flap viability. This study aimed to compare the effects of most commonly used phosphodiesterase type 5 (PDE5) inhibitors on flap survival. METHODS: A 3 × 9 cm flap was elevated from the dorsum of 32 Wistar albino rats. In the control group, saline was administered 2 hours before the flap elevation and continued for 2 days after the surgery. In the sildenafil, tadalafil, and vardenafil groups, the related drug was administered. Blood flow in the flaps was monitored with laser Doppler flowmetry. On postoperative day 7, flaps were photographed and biopsies were obtained. RESULTS: The ratios of flap necrosis area in the tadalafil, sildenafil, and vardenafil groups were lower than that in the control group, but without significant difference (p = 0.077). Histopathological evaluation revealed no significant difference among the groups. CONCLUSION: The ratio of flap necrosis area tended to be lower in the groups receiving oral PDE5 inhibitors than in the control group, although not statistically significant. The role of PDE5 inhibitors needs to be evaluated in larger studies before a conclusion can be made regarding their effects on flap viability.
OBJECTIVE: The most important issue in flap surgery is flap viability. This study aimed to compare the effects of most commonly used phosphodiesterase type 5 (PDE5) inhibitors on flap survival. METHODS: A 3 × 9 cm flap was elevated from the dorsum of 32 Wistar albino rats. In the control group, saline was administered 2 hours before the flap elevation and continued for 2 days after the surgery. In the sildenafil, tadalafil, and vardenafil groups, the related drug was administered. Blood flow in the flaps was monitored with laser Doppler flowmetry. On postoperative day 7, flaps were photographed and biopsies were obtained. RESULTS: The ratios of flap necrosis area in the tadalafil, sildenafil, and vardenafil groups were lower than that in the control group, but without significant difference (p = 0.077). Histopathological evaluation revealed no significant difference among the groups. CONCLUSION: The ratio of flap necrosis area tended to be lower in the groups receiving oral PDE5 inhibitors than in the control group, although not statistically significant. The role of PDE5 inhibitors needs to be evaluated in larger studies before a conclusion can be made regarding their effects on flap viability.
Entities:
Keywords:
Flaps; necrosis; phosphodiesterase type 5 inhibitors; sildenafil; tadalafil; vardenafil
Authors: Mohamed A Ellabban; Islam Omar Abdel Fattah; Ghada Abdel Kader; Omar Salah Eldeen; Amir E Mehana; Dina M Khodeer; Hossam Hosny; Mahmoud S Elbasiouny; Suhail Masadeh Journal: Sci Rep Date: 2020-02-21 Impact factor: 4.379
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