Ignacio Sánchez-Lázaro1, María José Herrero2,3, Consuelo Jordán-De Luna2,4, Virginia Bosó2,4, Luis Almenar1, Luis Rojas2,5, Luis Martínez-Dolz1, Juan E Megías-Vericat2,4, Luis Sendra3, Antonio Miguel3, José L Poveda4, Salvador F Aliño2,3,6. 1. Unidad de Insuficiencia Cardiaca y Transplante, Servicio de Cardiología, Hospital Universitario y Politécnico La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, Spain. 2. Unidad de Farmacogenética, Instituto Investigación Sanitaria La Fe & Área del Medicamento, Hospital Universitario y Politécnico La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, Spain. 3. Departamento Farmacología, Facultad de Medicina, Universidad de Valencia, Av. Blasco Ibáñez, 15, 46010 Valencia, Spain. 4. Servicio de Farmacia, Área del Medicamento, Hospital Universitario y Politécnico La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, Spain. 5. Department of Internal Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Libertador Bernardo O Higgins 340, Santiago, Chile. 6. Unidad de Farmacología Clínica, Área del Medicamento, Hospital Universitario y Politécnico La Fe, Av. Fernando Abril Martorell, 106, 46026 Valencia, Spain.
Abstract
AIM: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. MATERIALS & METHODS: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters during the first post-transplantation year. RESULTS: The presence of serious infections was correlated to ABCB1 rs1128503 (p = 0.012), CC genotype reduced the probability of infections being also associated with lower blood cyclosporine concentrations. Lower renal function levels were found in patients with rs9282564 AG (p = 0.003), related to higher blood cyclosporine blood levels. A tendency toward increased graft rejection (p = 0.05) was correlated to rs2066844 CC in NOD2/CARD15, a gene related to lymphocyte activation. CONCLUSION: Pharmacogenetics can help identify patients at increased risk of clinical complications. Original submitted 30 January 2015; revision submitted 27 March 2015.
AIM: Studying the possible influence of SNPs on efficacy and safety of calcineurin inhibitors upon heart transplantation. MATERIALS & METHODS: In 60 heart transplant patients treated with tacrolimus or cyclosporine, we studied a panel of 36 SNPs correlated with a series of clinical parameters during the first post-transplantation year. RESULTS: The presence of serious infections was correlated to ABCB1rs1128503 (p = 0.012), CC genotype reduced the probability of infections being also associated with lower blood cyclosporine concentrations. Lower renal function levels were found in patients with rs9282564 AG (p = 0.003), related to higher blood cyclosporine blood levels. A tendency toward increased graft rejection (p = 0.05) was correlated to rs2066844 CC in NOD2/CARD15, a gene related to lymphocyte activation. CONCLUSION: Pharmacogenetics can help identify patients at increased risk of clinical complications. Original submitted 30 January 2015; revision submitted 27 March 2015.
Authors: Jessica van Setten; Evangeline G Warmerdam; Olivier Q Groot; Nicolaas de Jonge; Brendan Keating; Folkert W Asselbergs Journal: Transplant Direct Date: 2019-01-21
Authors: Kris Oreschak; Laura M Saba; Nicholas Rafaels; Amrut V Ambardekar; Kimberly M Deininger; Robert L Page; JoAnn Lindenfeld; Christina L Aquilante Journal: Front Genet Date: 2021-04-01 Impact factor: 4.599