Ulla B Knudsen1, Camilla S Kronborg2, Peter von Dadelszen3, Ken Kupfer4, Seok-Won Lee4, Erik Vittinghus2, Jim G Allen2, Christopher W Redman5. 1. Department of Obstetrics and Gynaecology, Randers Hospital, Denmark. Electronic address: ubk@dadlnet.dk. 2. Department of Obstetrics and Gynaecology, Randers Hospital, Denmark. 3. Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada. 4. Alere, San Diego, CA, United States. 5. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Abstract
OBJECTIVES: To evaluate the clinical performance of a rapid point-of-care test, Triage PLGF (Alere, San Diego) in the diagnosis of preeclampsia. STUDY DESIGN: For the reference range 2212 plasma samples were collected from 595 subjects with normotensive pregnancies, between week 17 of gestation and delivery. In the case-control part, two cohorts of women with preeclampsia (80 women) were matched for maternal age, gestational age (GA) at sampling and parity with normotensive women who delivered at 37weeks or more. RESULTS: The areas under the receiver operating characteristic curves (GA<35weeks) were 1.0 and 0.994 (cohort 1 and 2, respectively). The clinical sensitivity of the Triage PLGF test for the pooled GA range of 21⩽GA<35, using a GA dependent cut-off, was 1.0 for both cohorts with specificities of 1.0 and 0.940. CONCLUSIONS: The Triage PLGF test distinguishes well between preterm pregnancies with and without preeclampsia.
OBJECTIVES: To evaluate the clinical performance of a rapid point-of-care test, Triage PLGF (Alere, San Diego) in the diagnosis of preeclampsia. STUDY DESIGN: For the reference range 2212 plasma samples were collected from 595 subjects with normotensive pregnancies, between week 17 of gestation and delivery. In the case-control part, two cohorts of women with preeclampsia (80 women) were matched for maternal age, gestational age (GA) at sampling and parity with normotensive women who delivered at 37weeks or more. RESULTS: The areas under the receiver operating characteristic curves (GA<35weeks) were 1.0 and 0.994 (cohort 1 and 2, respectively). The clinical sensitivity of the Triage PLGF test for the pooled GA range of 21⩽GA<35, using a GA dependent cut-off, was 1.0 for both cohorts with specificities of 1.0 and 0.940. CONCLUSIONS: The Triage PLGF test distinguishes well between preterm pregnancies with and without preeclampsia.
Authors: H Lehnen; N Mosblech; T Reineke; A Puchooa; I Menke-Möllers; U Zechner; U Gembruch Journal: Geburtshilfe Frauenheilkd Date: 2013-05 Impact factor: 2.915
Authors: M Griffin; P T Seed; L Webster; J Myers; L MacKillop; N Simpson; D Anumba; A Khalil; M Denbow; A Sau; K Hinshaw; P von Dadelszen; S Benton; J Girling; C W G Redman; L C Chappell; A H Shennan Journal: Ultrasound Obstet Gynecol Date: 2015-07-03 Impact factor: 7.299
Authors: Suzy Duckworth; Lucy C Chappell; Paul T Seed; Lucy Mackillop; Andrew H Shennan; Rachael Hunter Journal: PLoS One Date: 2016-10-14 Impact factor: 3.240
Authors: Nándor Gábor Than; Andrea Balogh; Roberto Romero; Eva Kárpáti; Offer Erez; András Szilágyi; Ilona Kovalszky; Marei Sammar; Sveinbjorn Gizurarson; János Matkó; Péter Závodszky; Zoltán Papp; Hamutal Meiri Journal: Front Immunol Date: 2014-08-20 Impact factor: 7.561