Masaki Ogawa1, Yoshio Matsuda2, Aiko Kobayashi2, Minoru Mitani2, Yasuo Makino2, Hideo Matsui2. 1. Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan. Electronic address: masakiogawa3@gmail.com. 2. Department of Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, Japan.
Abstract
OBJECTIVE: To analyze the antithrombin-III (AT-III) activity in the plasma in relation to the serum albumin and total protein in preeclampsia and gestational hypertension. STUDY DESIGN: The medical records of 139 patients who were diagnosed with gestational hypertension (n=33) and preeclampsia (n=106) were reviewed, and the relationships between the activity of AT-III and serum albumin or total protein were evaluated. MAIN OUTCOME MEASURES: The plasma AT-III activity in gestational hypertension and preeclampsia was correlated with the serum albumin and TP levels. RESULTS: There were significant correlations between AT-III activity and albumin in gestational hypertension (r=0.504, p=0.003) and preeclampsia (r=0.343, p=0.003). There were also significant correlations between AT-III activity and TP in gestational hypertension (r=0.619, p=0.001) and preeclampsia (r=0.366, p=0.001). Regression coefficients between AT-III and albumin and between AT-III and TP in gestational hypertension (23.7 and 14.0, respectively) were significantly steeper than those in preeclampsia (14.6 and 9.6, respectively). CONCLUSIONS: The plasma AT-III activity in gestational hypertension and preeclampsia was correlated with the serum albumin and TP levels. This suggests that AT-III activity is more likely to decrease in gestational hypertension than in preeclampsia.
OBJECTIVE: To analyze the antithrombin-III (AT-III) activity in the plasma in relation to the serum albumin and total protein in preeclampsia and gestational hypertension. STUDY DESIGN: The medical records of 139 patients who were diagnosed with gestational hypertension (n=33) and preeclampsia (n=106) were reviewed, and the relationships between the activity of AT-III and serum albumin or total protein were evaluated. MAIN OUTCOME MEASURES: The plasma AT-III activity in gestational hypertension and preeclampsia was correlated with the serum albumin and TP levels. RESULTS: There were significant correlations between AT-III activity and albumin in gestational hypertension (r=0.504, p=0.003) and preeclampsia (r=0.343, p=0.003). There were also significant correlations between AT-III activity and TP in gestational hypertension (r=0.619, p=0.001) and preeclampsia (r=0.366, p=0.001). Regression coefficients between AT-III and albumin and between AT-III and TP in gestational hypertension (23.7 and 14.0, respectively) were significantly steeper than those in preeclampsia (14.6 and 9.6, respectively). CONCLUSIONS: The plasma AT-III activity in gestational hypertension and preeclampsia was correlated with the serum albumin and TP levels. This suggests that AT-III activity is more likely to decrease in gestational hypertension than in preeclampsia.