Literature DB >> 26104353

High-Throughput DNA Sequencing Analysis of Antibody Repertoires.

Scott D Boyd1, Shilpa A Joshi1.   

Abstract

New high-throughput DNA sequencing (HTS) technologies developed in the past decade have begun to be applied to the study of the complex gene rearrangements that encode human antibodies. This article first reviews the genetic features of Ig loci and the HTS technologies that have been applied to human repertoire studies, then discusses key choices for experimental design and data analysis in these experiments and the insights gained in immunological and infectious disease studies with the use of these approaches.

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Year:  2014        PMID： 26104353     DOI： 10.1128/microbiolspec.AID-0017-2014

Source DB:  PubMed          Journal:  Microbiol Spectr        ISSN： 2165-0497


  11 in total

1.  A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing.

Authors:  Trisha A Rettig; Michael J Pecaut; Stephen K Chapes
Journal:  FASEB Bioadv       Date:  2018-08-30

Review 2.  V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation.

Authors:  Xiying Chi; Yue Li; Xiaoyan Qiu
Journal:  Immunology       Date:  2020-02-27       Impact factor: 7.397

3.  Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data.

Authors:  Namita T Gupta; Kristofor D Adams; Adrian W Briggs; Sonia C Timberlake; Francois Vigneault; Steven H Kleinstein
Journal:  J Immunol       Date:  2017-02-08       Impact factor: 5.422

4.  Next generation sequencing reveals changes of the γδ T cell receptor repertoires in patients with pulmonary tuberculosis.

Authors:  Chaofei Cheng; Bei Wang; Lei Gao; Jianmin Liu; Xinchun Chen; He Huang; Zhendong Zhao
Journal:  Sci Rep       Date:  2018-03-02       Impact factor: 4.379

Review 5.  The Individual and Population Genetics of Antibody Immunity.

Authors:  Corey T Watson; Jacob Glanville; Wayne A Marasco
Journal:  Trends Immunol       Date:  2017-05-20       Impact factor: 16.687

6.  Network Organization of Antibody Interactions in Sequence and Structure Space: the RADARS Model.

Authors:  József Prechl
Journal:  Antibodies (Basel)       Date:  2020-05-06

7.  A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing.

Authors:  Trisha A Rettig; Michael J Pecaut; Stephen K Chapes
Journal:  FASEB Bioadv       Date:  2018-10-25

8.  CRIS: complete reconstruction of immunoglobulin V-D-J sequences from RNA-seq data.

Authors:  Rashedul Islam; Misha Bilenky; Andrew P Weng; Joseph M Connors; Martin Hirst
Journal:  Bioinform Adv       Date:  2021-09-09

Review 9.  Practical guidelines for B-cell receptor repertoire sequencing analysis.

Authors:  Gur Yaari; Steven H Kleinstein
Journal:  Genome Med       Date:  2015-11-20       Impact factor: 11.117

10.  Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response.

Authors:  Xuefeng Niu; Qihong Yan; Zhipeng Yao; Fan Zhang; Linbing Qu; Chunlin Wang; Chengrui Wang; Hui Lei; Chaoming Chen; Renshan Liang; Jia Luo; Qian Wang; Lingzhai Zhao; Yudi Zhang; Kun Luo; Longyu Wang; Hongkai Wu; Tingting Liu; Pingchao Li; Zhiqiang Zheng; Yee Joo Tan; Liqiang Feng; Zhenhai Zhang; Jian Han; Fuchun Zhang; Ling Chen
Journal:  Emerg Microbes Infect       Date:  2020-01-06       Impact factor: 7.163
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