David Hall1, Stefan Gebhardt2, Gerhard Theron3, Debbie Grové3. 1. Department of Obstetrics and Gynecology, Stellenbosch University and Tygerberg Hospital, South Africa. Electronic address: drh@sun.ac.za. 2. Department of Obstetrics and Gynecology, Stellenbosch University and Tygerberg Hospital, South Africa; Department of Obstetrics and Gynecology, Paarl Hospital, South Africa. 3. Department of Obstetrics and Gynecology, Stellenbosch University and Tygerberg Hospital, South Africa.
Abstract
OBJECTIVE: To determine whether pre-eclampsia and gestational hypertension are less common in HIV infected women. METHODS: This prospective cohort study was performed in the Western Cape province of South Africa. HIV negative and positive pregnant women without chronic renal or chronic hypertensive disease were continuously recruited. During the study period HIV positive patients received either mono- or triple (HAART) antiretroviral therapy for prevention of vertical transmission or maternal care. Only routine clinical management was performed. The development of hypertensive disease during pregnancy was recorded. RESULTS: 1093 HIV positive and 1173 HIV negative cases were identified during pregnancy and evaluated again after delivery. Significantly fewer cases of pre-eclampsia n=35 (3.2%) were recorded in the HIV positive group than in the HIV negative group, n=57 (4.9%) (p=0.045; OR 0.65 95% CI 0.42-0.99). There were also significantly fewer cases of gestational hypertension recorded in the HIV positive group compared to the HIV negative group (p=0.026; OR 0.53 95% CI 0.30-0.94). Multiple logistic regression analysis confirmed the reductive effect of HIV on pre-eclampsia and gestational hypertension. CONCLUSION: Pre-eclampsia and gestational hypertension are less common in HIV infected women being managed with mono- or triple anti-retroviral therapy.
OBJECTIVE: To determine whether pre-eclampsia and gestational hypertension are less common in HIV infectedwomen. METHODS: This prospective cohort study was performed in the Western Cape province of South Africa. HIV negative and positive pregnant women without chronic renal or chronic hypertensive disease were continuously recruited. During the study period HIV positive patients received either mono- or triple (HAART) antiretroviral therapy for prevention of vertical transmission or maternal care. Only routine clinical management was performed. The development of hypertensive disease during pregnancy was recorded. RESULTS: 1093 HIV positive and 1173 HIV negative cases were identified during pregnancy and evaluated again after delivery. Significantly fewer cases of pre-eclampsia n=35 (3.2%) were recorded in the HIV positive group than in the HIV negative group, n=57 (4.9%) (p=0.045; OR 0.65 95% CI 0.42-0.99). There were also significantly fewer cases of gestational hypertension recorded in the HIV positive group compared to the HIV negative group (p=0.026; OR 0.53 95% CI 0.30-0.94). Multiple logistic regression analysis confirmed the reductive effect of HIV on pre-eclampsia and gestational hypertension. CONCLUSION: Pre-eclampsia and gestational hypertension are less common in HIV infectedwomen being managed with mono- or triple anti-retroviral therapy.
Authors: Michele K Saums; Caroline C King; Jenna C Adams; Anandi N Sheth; Martina L Badell; Marisa Young; Lynn M Yee; Ellen G Chadwick; Denise J Jamieson; Lisa B Haddad Journal: Obstet Gynecol Date: 2019-12 Impact factor: 7.661
Authors: Joan T Price; Bellington Vwalika; Jessie K Edwards; Stephen R Cole; Margaret P Kasaro; Katelyn J Rittenhouse; Andrew Kumwenda; Mwansa K Lubeya; Jeffrey S A Stringer Journal: J Acquir Immune Defic Syndr Date: 2021-06-01 Impact factor: 3.771