Literature DB >> 26103989

Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics.

Timothy H Ung1, Hani Malone1, Peter Canoll2, Jeffrey N Bruce1.   

Abstract

Glioblastoma is the most common primary brain tumor in adults and carries a dismal prognosis despite advancements in treatment. Diffuse tumor infiltration precludes curative surgical resection and necessitates advancements in drug delivery mechanisms. Convection-enhanced delivery (CED) enables continuous local drug delivery for a diverse population of antitumor agents. Importantly, CED circumvents therapeutic challenges posed by the blood-brain barrier by facilitating concentrated local therapeutic drug delivery with limited systemic effects. Here, we present a concise review of properties essential for safe and efficient convection-enhanced drug delivery, as well as a focused review of clinical studies evaluating CED in the treatment of glioblastoma.

Entities:  

Keywords:  convection-enhanced delivery; glioblastoma; glioma; high-grade glioma; targeted delivery of therapeutics for glioblastoma

Mesh：

Substances：

Year:  2015        PMID： 26103989      PMCID： PMC6088338          DOI： 10.2217/cns.15.12

Source DB:  PubMed          Journal:  CNS Oncol        ISSN： 2045-0907


  46 in total

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Journal:  Neuro Oncol       Date:  2000-01       Impact factor: 12.300

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Journal:  Cancer Treat Rev       Date:  1998-10       Impact factor: 12.111

Review 5.  Convection-enhanced delivery in the treatment of malignant glioma.

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Journal:  Neurol Res       Date:  2006-07       Impact factor: 2.448

6.  Convection-enhanced delivery of macromolecules in the brain.

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Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

Review 7.  Topoisomerase I inhibitors: camptothecins and beyond.

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8.  A North Central Cancer Treatment Group phase II trial of topotecan in relapsed gliomas.

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Journal:  Invest New Drugs       Date:  2000-08       Impact factor: 3.850

9.  Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.

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Journal:  Neuro Oncol       Date:  2007-04-13       Impact factor: 12.300

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Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333
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  10 in total

Review 1.  Convection-Enhanced Delivery.

Authors:  A M Mehta; A M Sonabend; J N Bruce
Journal:  Neurotherapeutics       Date:  2017-04       Impact factor: 7.620

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Authors:  Gregory D Arnone; Abhiraj D Bhimani; Tania Aguilar; Ankit I Mehta
Journal:  J Neurooncol       Date:  2018-01-11       Impact factor: 4.130

3.  Biocompatibility of the fiberoptic microneedle device chronically implanted in the rat brain.

Authors:  Yukitaka Kani; Jonathan Hinckley; John L Robertson; Jason M Mehta; Christopher G Rylander; John H Rossmeisl
Journal:  Res Vet Sci       Date:  2021-12-31       Impact factor: 2.534

Review 4.  Convection-Enhanced Delivery in Children: Techniques and Applications.

Authors:  K Aquilina; A Chakrapani; L Carr; M A Kurian; D Hargrave
Journal:  Adv Tech Stand Neurosurg       Date:  2022

Review 5.  Drug Delivery Systems in the Development of Novel Strategies for Glioblastoma Treatment.

Authors:  Wiam El Kheir; Bernard Marcos; Nick Virgilio; Benoit Paquette; Nathalie Faucheux; Marc-Antoine Lauzon
Journal:  Pharmaceutics       Date:  2022-06-01       Impact factor: 6.525

6.  Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts.

Authors:  Jeffrey D Serrill; Xuemei Wan; Andrew M Hau; Hyo Sang Jang; Daniel J Coleman; Arup K Indra; Adam W G Alani; Kerry L McPhail; Jane E Ishmael
Journal:  Invest New Drugs       Date:  2015-11-12       Impact factor: 3.850

7.  Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.

Authors:  Kendra A Porath; Michael S Regan; Jessica I Griffith; Sonia Jain; Sylwia A Stopka; Danielle M Burgenske; Katrina K Bakken; Brett L Carlson; Paul A Decker; Rachael A Vaubel; Sonja Dragojevic; Ann C Mladek; Margaret A Connors; Zeng Hu; Lihong He; Gaspar J Kitange; Shiv K Gupta; Thomas M Feldsien; Didier R Lefebvre; Nathalie Y R Agar; Jeanette E Eckel-Passow; Edward B Reilly; William F Elmquist; Jann N Sarkaria
Journal:  Neurooncol Adv       Date:  2022-08-24

Review 8.  Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience.

Authors:  Pavan S Upadhyayula; Eleonora F Spinazzi; Michael G Argenziano; Peter Canoll; Jeffrey N Bruce
Journal:  Pharmaceutics       Date:  2020-12-30       Impact factor: 6.321

Review 9.  A perspective on the radiopharmaceutical requirements for imaging and therapy of glioblastoma.

Authors:  Julie Bolcaen; Janke Kleynhans; Shankari Nair; Jeroen Verhoeven; Ingeborg Goethals; Mike Sathekge; Charlot Vandevoorde; Thomas Ebenhan
Journal:  Theranostics       Date:  2021-07-06       Impact factor: 11.556

Review 10.  Electrotherapies for Glioblastoma.

Authors:  Elise P W Jenkins; Alina Finch; Magda Gerigk; Iasonas F Triantis; Colin Watts; George G Malliaras
Journal:  Adv Sci (Weinh)       Date:  2021-07-22       Impact factor: 16.806
  10 in total

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