I R Postma1, H Groen2, T R Easterling3, E Z Tsigas4, M L Wilson5, J Porcel5, G G Zeeman6. 1. Department of Obstetrics and Gynaecology, University Medical Center Groningen, University of Groningen, The Netherlands. Electronic address: i.r.postma@umcg.nl. 2. Department of Epidemiology, University Medical Center Groningen, University of Groningen, The Netherlands. 3. Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA. 4. Preeclampsia Foundation, Melbourne, FL, USA. 5. Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA. 6. Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus Medical Center Rotterdam, The Netherlands.
Abstract
OBJECTIVES: Previously preeclamptic women may express cognitive difficulties, which have largely been unappreciated or attributed to stresses of a complicated pregnancy. This study aimed to explore the scope of perceived neurocognitive and psychosocial problems as well as quality of life following preeclampsia. STUDY DESIGN: Observational study. Through website promotion and e-mail, registrants of the USA-based Preeclampsia Foundation who experienced preeclampsia in the past 20years were invited to complete a web-based survey. Participants were requested to ask an acquaintance that had a normotensive pregnancy to also complete the survey (controls). MAIN OUTCOME MEASURES: The Cognitive Failures Questionnaire (CFQ), abbreviated WHO Quality Of Life questionnaire (WHOQOL-BREF), Social Functioning Questionnaire (SFQ) and Breslau Short Screening Scale for DSM-IV Posttraumatic Stress Disorder were used in the survey. Analysis was performed using Mann-Whitney U tests and linear regression. RESULTS: 966 cases and 342 controls completed the survey (median age 34, median time since first pregnancy 4 vs. 5years). Cases scored significantly worse on CFQ (median 35 vs. 27), WHOQOL-BREF domains physical health (15 vs. 17), psychological (13 vs. 15), social relationships (13 vs. 15) and environment (15 vs. 16), and SFQ (8 vs. 7). All p<0.001. Multivariable analysis showed an independent significant effect of eclampsia on CFQ and of migraine on all questionnaires and the effect of preeclampsia was still present after adjustment for confounders. Posttraumatic stress symptoms accounted for part of the relationships. CONCLUSIONS: Previously preeclamptic women appear to perceive more cognitive and social problems, and report poorer quality of life compared to a group of women with normotensive pregnancies. Research relating to the origin and management of these issues is needed.
OBJECTIVES: Previously preeclamptic women may express cognitive difficulties, which have largely been unappreciated or attributed to stresses of a complicated pregnancy. This study aimed to explore the scope of perceived neurocognitive and psychosocial problems as well as quality of life following preeclampsia. STUDY DESIGN: Observational study. Through website promotion and e-mail, registrants of the USA-based Preeclampsia Foundation who experienced preeclampsia in the past 20years were invited to complete a web-based survey. Participants were requested to ask an acquaintance that had a normotensive pregnancy to also complete the survey (controls). MAIN OUTCOME MEASURES: The Cognitive Failures Questionnaire (CFQ), abbreviated WHO Quality Of Life questionnaire (WHOQOL-BREF), Social Functioning Questionnaire (SFQ) and Breslau Short Screening Scale for DSM-IV Posttraumatic Stress Disorder were used in the survey. Analysis was performed using Mann-Whitney U tests and linear regression. RESULTS: 966 cases and 342 controls completed the survey (median age 34, median time since first pregnancy 4 vs. 5years). Cases scored significantly worse on CFQ (median 35 vs. 27), WHOQOL-BREF domains physical health (15 vs. 17), psychological (13 vs. 15), social relationships (13 vs. 15) and environment (15 vs. 16), and SFQ (8 vs. 7). All p<0.001. Multivariable analysis showed an independent significant effect of eclampsia on CFQ and of migraine on all questionnaires and the effect of preeclampsia was still present after adjustment for confounders. Posttraumatic stress symptoms accounted for part of the relationships. CONCLUSIONS: Previously preeclamptic women appear to perceive more cognitive and social problems, and report poorer quality of life compared to a group of women with normotensive pregnancies. Research relating to the origin and management of these issues is needed.
Authors: Julie A Fields; Vesna D Garovic; Michelle M Mielke; Kejal Kantarci; Muthuvel Jayachandran; Wendy M White; Alissa M Butts; Jonathan Graff-Radford; Brian D Lahr; Kent R Bailey; Virginia M Miller Journal: Am J Obstet Gynecol Date: 2017-03-18 Impact factor: 8.661
Authors: Timo Siepmann; Henry Boardman; Amy Bilderbeck; Ludovica Griffanti; Yvonne Kenworthy; Charlotte Zwager; David McKean; Jane Francis; Stefan Neubauer; Grace Z Yu; Adam J Lewandowski; Yrsa Bergmann Sverrisdottir; Paul Leeson Journal: Neurology Date: 2017-02-24 Impact factor: 9.910
Authors: Mark A Brown; Lynne Roberts; Anna Hoffman; Amanda Henry; George Mangos; Anthony O'Sullivan; Franziska Pettit; George Youssef; Lily Xu; Gregory K Davis Journal: J Am Heart Assoc Date: 2020-11-10 Impact factor: 5.501
Authors: Maria C Adank; Rowina F Hussainali; Lise C Oosterveer; M Arfan Ikram; Eric A P Steegers; Eliza C Miller; Sarah Schalekamp-Timmermans Journal: Neurology Date: 2020-12-30 Impact factor: 9.910
Authors: Carolien N H Abheiden; Rebecca van Doornik; Annet M Aukes; Wiesje M van der Flier; Philip Scheltens; Christianne J M de Groot Journal: Dement Geriatr Cogn Dis Extra Date: 2015-09-30