Literature DB >> 26103205

The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques.

Kaixiang Zhou1, Hualong Fu, Liang Feng, Mengchao Cui, Jiapei Dai, Boli Liu.   

Abstract

A new array of near-infrared probes containing barbituric acid acceptors has been developed as Aβ imaging agents. These probes displayed long-emission wavelengths and large Stokes shifts, as well as high affinities for Aβ aggregates. In vivo and ex vivo studies demonstrated that BBTOM-3 could intensely label Aβ plaques in the brains of transgenic mice.

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Year:  2015        PMID: 26103205     DOI: 10.1039/c5cc03662c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

1.  Barbituric Acid Based Fluorogens: Synthesis, Aggregation-Induced Emission, and Protein Fibril Detection.

Authors:  Siyang Ding; Bicheng Yao; Louis Schobben; Yuning Hong
Journal:  Molecules       Date:  2019-12-20       Impact factor: 4.411

2.  Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes.

Authors:  Jusung An; Peter Verwilst; Hira Aziz; Jinwoo Shin; Sungsu Lim; Ilwha Kim; Yun Kyung Kim; Jong Seung Kim
Journal:  Bioact Mater       Date:  2021-11-09

3.  Engineering of donor-acceptor-donor curcumin analogues as near-infrared fluorescent probes for in vivo imaging of amyloid-β species.

Authors:  Daqing Fang; Xidan Wen; Yuqi Wang; Yidan Sun; Ruibing An; Yu Zhou; Deju Ye; Hong Liu
Journal:  Theranostics       Date:  2022-04-04       Impact factor: 11.600

  3 in total

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