Tobias Schoen1, Eva-Maria Hohmann, Stephanie Van Der Lely, Stefanie Aeschbacher, Andreas Reusser, Martin Risch, Lorenz Risch, David Conen. 1. aDepartment of Medicine, University Hospital Basel bCardiovascular Research Institute Basel, Switzerland cUniversity Heart Center Freiburg - Bad Krozingen, Germany dLabormedizinisches Zentrum Dr Risch, Schaan FL eDivision of Laboratory Medicine, Kantonsspital Graubünden, Chur, Switzerland fDivision of Clinical Biochemistry, Medical University Innsbruck, Innsbruck, Austria gPrivate University, Triesen, Liechtenstein *Tobias Schoen and Eva-Maria Hohmann contributed equally to the writing of this article and are joint first authors.
Abstract
OBJECTIVE: We investigated whether copeptin - a well characterized vasopressin-related stress hormone - is associated with circadian ambulatory blood pressure (BP) variability and/or mean BP levels in young adults. METHOD AND RESULTS: We studied a population-based sample of healthy adults aged 25-41 years. Individuals with diabetes, treated hypertension, and cardiovascular disease were excluded. Ambulatory 24-h BP monitoring was performed using validated devices. To evaluate the relationships of copeptin with mean ambulatory BP levels and BP variability during daytime and night-time, multivariable adjusted regression models were constructed. BP variability was defined as SD of all intraindividual BP values. Of the 2012 individuals included in this study, 53% were women and the median age was 37 years. Median plasma copeptin levels were 3.9 (interquartile range 2.7, 5.8) in men and 2.3 pmol/l (interquartile range 1.6, 3.6) in women (P < 0.0001). In multivariable linear regression models, log-transformed copeptin was significantly associated with systolic and diastolic night-time BP levels among men [β = 1.9, 95% confidence interval (CI) 0.6, 3.1, P = 0.003; and β = 1.4, 95% CI 0.6, 2.3, P = 0.001, respectively], but not among women. In addition, copeptin was strongly associated with an increased systolic and diastolic daytime (β = 0.5, 95% CI 0.2, 0.7, P = 0.001; β = 0.5, 95% CI 0.3, 0.8, P < 0.0001, respectively) and night-time BP variability (β = 0.6, 95% CI 0.3, 0.9, P = 0.0002; β = 0.4, 95% CI 0.2, 0.7, P = 0.002, respectively). CONCLUSION: In this large population-based study of young and healthy adults, plasma levels of copeptin were significantly associated with an increased BP variability in both sexes and an elevated night-time BP among men.
OBJECTIVE: We investigated whether copeptin - a well characterized vasopressin-related stress hormone - is associated with circadian ambulatory blood pressure (BP) variability and/or mean BP levels in young adults. METHOD AND RESULTS: We studied a population-based sample of healthy adults aged 25-41 years. Individuals with diabetes, treated hypertension, and cardiovascular disease were excluded. Ambulatory 24-h BP monitoring was performed using validated devices. To evaluate the relationships of copeptin with mean ambulatory BP levels and BP variability during daytime and night-time, multivariable adjusted regression models were constructed. BP variability was defined as SD of all intraindividual BP values. Of the 2012 individuals included in this study, 53% were women and the median age was 37 years. Median plasma copeptin levels were 3.9 (interquartile range 2.7, 5.8) in men and 2.3 pmol/l (interquartile range 1.6, 3.6) in women (P < 0.0001). In multivariable linear regression models, log-transformed copeptin was significantly associated with systolic and diastolic night-time BP levels among men [β = 1.9, 95% confidence interval (CI) 0.6, 3.1, P = 0.003; and β = 1.4, 95% CI 0.6, 2.3, P = 0.001, respectively], but not among women. In addition, copeptin was strongly associated with an increased systolic and diastolic daytime (β = 0.5, 95% CI 0.2, 0.7, P = 0.001; β = 0.5, 95% CI 0.3, 0.8, P < 0.0001, respectively) and night-time BP variability (β = 0.6, 95% CI 0.3, 0.9, P = 0.0002; β = 0.4, 95% CI 0.2, 0.7, P = 0.002, respectively). CONCLUSION: In this large population-based study of young and healthy adults, plasma levels of copeptin were significantly associated with an increased BP variability in both sexes and an elevated night-time BP among men.
Authors: Mehmet Kanbay; Gamze Aslan; Baris Afsar; Tuncay Dagel; Dimitrie Siriopol; Masanari Kuwabara; Said Incir; Volkan Camkiran; Bernardo Rodriguez-Iturbe; Miguel A Lanaspa; Adrian Covic; Richard J Johnson Journal: J Clin Hypertens (Greenwich) Date: 2018-09-19 Impact factor: 3.738
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