Literature DB >> 26102520

Probing the Mucoadhesive Interactions Between Porcine Gastric Mucin and Some Water-Soluble Polymers.

Yasser A Albarkah1, Rebecca J Green1, Vitaliy V Khutoryanskiy2.   

Abstract

This study investigates the structural features of porcine gastric mucin (PGM) in aqueous dispersions and its interactions with water-soluble polymers (poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly(ethylene oxide), and poly(ethylene glycol)) using isothermal titration calorimetry, turbidimetric titration, dynamic light scattering, and transmission electron microscopy. It is established that PAA (450 kDa) and PMAA (100 kDa) exhibit strong specific interactions with PGM causing further aggregation of its particles, while PAA (2 kDa), poly(ethylene oxide) (1 000 kDa), and poly(ethylene glycol) (10 kDa) do not show any detectable effects on mucin. Sonication of mucin dispersions prior to their mixing with PAA (450 kDa) and PMAA (100 kDa) leads to more pronounced intensity of interactions.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  hydrogen bonding; isothermal titration calorimetry; mucoadhesion; porcine gastric mucin; water-soluble polymers

Mesh：

Substances：

Year:  2015        PMID： 26102520     DOI： 10.1002/mabi.201500158

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  7 in total

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Authors:  Guzel K Abilova; Daulet B Kaldybekov; Galiya S Irmukhametova; Diara S Kazybayeva; Zhanar A Iskakbayeva; Sarkyt E Kudaibergenov; Vitaliy V Khutoryanskiy
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7.  Peptide-Mucin Binding and Biosimilar Mucus-Permeating Properties.

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  7 in total

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