Literature DB >> 26102368

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach.

Kodai Saito1, Yuka Moriya1, Takahiko Akiyama1.   

Abstract

Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities.

Entities:  

Year:  2015        PMID： 26102368     DOI： 10.1021/acs.orglett.5b01654

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

Review 1.  Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.

Authors:  Imtiaz Khan; Aliya Ibrar; Sumera Zaib
Journal:  Top Curr Chem (Cham)       Date:  2021-01-05

2.  Highly Enantioselective Catalytic Addition of Grignard Reagents to N-Heterocyclic Acceptors.

Authors:  Yafei Guo; Syuzanna R Harutyunyan
Journal:  Angew Chem Int Ed Engl       Date:  2019-07-30       Impact factor: 15.336
  2 in total

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