| Literature DB >> 26101933 |
Amit Sharma1, David F Boyd1,2, Julie Overbaugh1.
Abstract
SHIV/macaque model is critical for pre-clinical HIV-1 research. The ability of this model to predict efficacious intervention(s) in humans depends on how faithfully the model recapitulates key features of HIV-1 transmission and pathogenesis. Here, we provide insights for rationally designing SHIVs with transmitted HIV-1 variants for vaccine and prevention research.Entities:
Keywords: HIV-1 envelope; SHIV/macaque model; transmitted/founder HIV-1
Mesh:
Year: 2015 PMID: 26101933 DOI: 10.1111/jmp.12179
Source DB: PubMed Journal: J Med Primatol ISSN: 0047-2565 Impact factor: 0.667