Naci Topaloglu1, Adem Kucuk2, Mustafa Tekin1, Sule Yildirim1, Mesut Erbas3, Hasan Ali Kiraz3, Dilek Ulker Cakir4, Havva Erdem5. 1. Department of Pediatrics, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey. 2. Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey. 3. Department of Anesthesiology, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey. 4. Department of Clinical Biochemistry, Çanakkale Onsekiz Mart University, Medical Faculty, Çanakkale, Turkey. 5. Department of Pathology, Düzce Atatürk State Hospital, Düzce, Turkey.
Abstract
OBJECTIVE: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Experimental Animal Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, from May to September 2013. METHODOLOGY:Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. RESULTS:Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. CONCLUSION: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.
RCT Entities:
OBJECTIVE: To establish whether the Ischemia-Modified Albumin (IMA), a new parameter of oxidative stress, has diagnostic role in experimental acute pancreatitis. STUDY DESIGN: Randomized controlled trial. PLACE AND DURATION OF STUDY: Experimental Animal Center, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, from May to September 2013. METHODOLOGY: Sixteen Sprague-Dawley rats were randomly divided into two groups (n=8 each): Sham and AP groups. AP was induced by ligation of pancreatic duct. Serum IMA, amylase, lipase, AST, ALT and CRP were determined. The severity of pancreatitis was scored by a blinded pathologist under microscope. RESULTS: Serum IMA levels in the AP group increased significantly compared with the control group (p < 0.05). There was also a strong positive correlation between amylase and IMA levels. CONCLUSION: The present study showed in a rodent model that serum IMA might serve as an additional marker to monitor inflammation during pancreatitis.