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Literature DB >> 26100515

Connexins and pannexins in the immune system and lymphatic organs.

Aaron M Glass¹, Elizabeth G Snyder, Steven M Taffet.

Abstract

Connexin43 and pannexin1 are found in immune cells. While gap junctional communication has been demonstrated between immune cells, hemichannels have been implicated in many cellular functions. Among the functions involved as being connexin dependent and pannexin dependent are cell migration, phagocytosis, antigen presentation, T-cell reactivity and B-cell responses. Surprisingly, many of these connexin-related and pannexin-related functions are not recapitulated in in vivo models. This is leading to a reevaluation of the role of these proteins in immune function.

Entities: Gene

Mesh：

Substances：
Connexins

Year: 2015 PMID： 26100515 DOI： 10.1007/s00018-015-1966-3

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

78 in total

1. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses.

Authors: Eliseo A Eugenín; María C Brañes; Joan W Berman; Juan C Sáez
Journal: J Immunol Date: 2003-02-01 Impact factor: 5.422

2. Cross-presentation by intercellular peptide transfer through gap junctions.

Authors: Joost Neijssen; Carla Herberts; Jan Wouter Drijfhout; Eric Reits; Lennert Janssen; Jacques Neefjes
Journal: Nature Date: 2005-03-03 Impact factor: 49.962

3. Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I.

Authors: Jeff D Colbert; Diego J Farfán-Arribas; Kenneth L Rock
Journal: J Immunol Date: 2013-10-30 Impact factor: 5.422

4. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex.

Authors: Silviu Locovei; Eliana Scemes; Feng Qiu; David C Spray; Gerhard Dahl
Journal: FEBS Lett Date: 2007-01-16 Impact factor: 4.124

5. Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity.

Authors: Fabiana Saccheri; Chiara Pozzi; Francesca Avogadri; Sara Barozzi; Mario Faretta; Paola Fusi; Maria Rescigno
Journal: Sci Transl Med Date: 2010-08-11 Impact factor: 17.956

6. A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection.

Authors: Rahul J Anand; Shipan Dai; Steven C Gribar; Ward Richardson; Jeff W Kohler; Rosemary A Hoffman; Maria F Branca; Jun Li; Xiao-Hua Shi; Chhinder P Sodhi; David J Hackam
Journal: J Immunol Date: 2008-12-15 Impact factor: 5.422

7. Connexin-43-type gap junctions mediate communication between bone marrow stromal cells.

Authors: K Dorshkind; L Green; A Godwin; W H Fletcher
Journal: Blood Date: 1993-07-01 Impact factor: 22.113

8. Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2.

Authors: Noemí Marina-García; Luigi Franchi; Yun-Gi Kim; Douglas Miller; Christine McDonald; Geert-Jan Boons; Gabriel Núñez
Journal: J Immunol Date: 2008-03-15 Impact factor: 5.422

9. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.

Authors: Tobias Bopp; Christian Becker; Matthias Klein; Stefan Klein-Hessling; Alois Palmetshofer; Edgar Serfling; Valeska Heib; Marc Becker; Jan Kubach; Steffen Schmitt; Sabine Stoll; Hansjörg Schild; Martin S Staege; Michael Stassen; Helmut Jonuleit; Edgar Schmitt
Journal: J Exp Med Date: 2007-05-14 Impact factor: 14.307

Review 10. Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells.

Authors: Pablo J Sáez; Kenji F Shoji; Adam Aguirre; Juan C Sáez
Journal: Mediators Inflamm Date: 2014-09-09 Impact factor: 4.711

24 in total

1. Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.

Authors: Stephanie J Munger; Michael J Davis; Alexander M Simon
Journal: Dev Biol Date: 2016-11-27 Impact factor: 3.582

2. Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43.

Authors: Claire E Trincot; Wenjing Xu; Hua Zhang; Molly R Kulikauskas; Thomas G Caranasos; Brian C Jensen; Amélie Sabine; Tatiana V Petrova; Kathleen M Caron
Journal: Circ Res Date: 2019-01-04 Impact factor: 17.367

Connexins and pannexins in the immune system and lymphatic organs.

1. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses.

2. Cross-presentation by intercellular peptide transfer through gap junctions.

3. Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I.

4. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex.

5. Bacteria-induced gap junctions in tumors favor antigen cross-presentation and antitumor immunity.

6. A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection.

7. Connexin-43-type gap junctions mediate communication between bone marrow stromal cells.

8. Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2.

9. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression.

Review 10. Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells.

1. Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.

2. Adrenomedullin Induces Cardiac Lymphangiogenesis After Myocardial Infarction and Regulates Cardiac Edema Via Connexin 43.

Review 3. Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Review 4. The role of connexin and pannexin containing channels in the innate and acquired immune response.

Review 5. Connexins and their channels in inflammation.

Review 6. Phagocytosis in Teleosts. Implications of the New Cells Involved.

7. Mast Cells Interact with Endothelial Cells to Accelerate In Vitro Angiogenesis.

Review 8. Inhibitors of connexin and pannexin channels as potential therapeutics.

Review 9. Lymphatic Connexins and Pannexins in Health and Disease.

10. Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination.