Literature DB >> 26100368

Hepatitis: After HCV cure, HBV cure?

Julie Lucifora1, Christian Trepo1.   

Abstract

Current treatments efficiently control chronic HBV infection but they do not lead to its elimination. Now, Ebert and colleagues have shown that cellular inhibitor of apoptosis proteins (cIAPs) prevent TNF-mediated killing of infected hepatocytes and that cIAP antagonists might lead to HBV cure by promoting death of infected cells.

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Year:  2015        PMID： 26100368     DOI： 10.1038/nrgastro.2015.103

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN： 1759-5045            Impact factor:   46.802


  9 in total

Review 1.  Management of treatment failure in chronic hepatitis B.

Authors:  Fabien Zoulim; Stephen Locarnini
Journal:  J Hepatol       Date:  2012       Impact factor: 25.083

Review 2.  Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis.

Authors:  Kewei Wang; Bingliang Lin
Journal:  Cell Signal       Date:  2013-06-11       Impact factor: 4.315

3.  Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus.

Authors:  Gregor Ebert; Simon Preston; Cody Allison; James Cooney; Jesse G Toe; Michael D Stutz; Samar Ojaimi; Hamish W Scott; Nikola Baschuk; Ueli Nachbur; Joseph Torresi; Ruth Chin; Danielle Colledge; Xin Li; Nadia Warner; Peter Revill; Scott Bowden; John Silke; C Glenn Begley; Marc Pellegrini
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-20       Impact factor: 11.205

4.  Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis.

Authors:  Gregor Ebert; Cody Allison; Simon Preston; James Cooney; Jesse G Toe; Michael D Stutz; Samar Ojaimi; Nikola Baschuk; Ueli Nachbur; Joseph Torresi; John Silke; C Glenn Begley; Marc Pellegrini
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-20       Impact factor: 11.205

5.  CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection.

Authors:  Robert Thimme; Stefan Wieland; Carola Steiger; John Ghrayeb; Keith A Reimann; Robert H Purcell; Francis V Chisari
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

Review 6.  From non-A, non-B hepatitis to hepatitis C virus cure.

Authors:  Jean-Michel Pawlotsky; Jordan J Feld; Stefan Zeuzem; Jay H Hoofnagle
Journal:  J Hepatol       Date:  2015-04       Impact factor: 25.083

7.  Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.

Authors:  Julie Lucifora; Yuchen Xia; Florian Reisinger; Ke Zhang; Daniela Stadler; Xiaoming Cheng; Martin F Sprinzl; Herwig Koppensteiner; Zuzanna Makowska; Tassilo Volz; Caroline Remouchamps; Wen-Min Chou; Wolfgang E Thasler; Norbert Hüser; David Durantel; T Jake Liang; Carsten Münk; Markus H Heim; Jeffrey L Browning; Emmanuel Dejardin; Maura Dandri; Michael Schindler; Mathias Heikenwalder; Ulrike Protzer
Journal:  Science       Date:  2014-02-20       Impact factor: 47.728

8.  Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance.

Authors:  Peixiang Lan; Cai Zhang; Qiuju Han; Jian Zhang; Zhigang Tian
Journal:  Hepatology       Date:  2013-05-23       Impact factor: 17.425

Review 9.  New pharmacological strategies to fight enveloped viruses.

Authors:  Karin Wisskirchen; Julie Lucifora; Thomas Michler; Ulrike Protzer
Journal:  Trends Pharmacol Sci       Date:  2014-08-06       Impact factor: 14.819
  9 in total
  2 in total

Review 1.  Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined Modalities.

Authors:  Sebastien Boucle; Leda Bassit; Maryam Ehteshami; Raymond F Schinazi
Journal:  Clin Liver Dis       Date:  2016-08-30       Impact factor: 6.126

2.  Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6.

Authors:  Kewei Wang; Minhua Wang; Maureen Gannon; AiXuan Holterman
Journal:  PLoS One       Date:  2016-12-09       Impact factor: 3.240
  2 in total

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