Nursen Keles1, Mustafa Caliskan1, Feyza Ulusoy Aksu1, Necibe Nur Keles2, Vildan Karagoz3, Ahmet Selami Tekin1, Mustafa Akcakoyun4, Osman Kostek5, Omer Elcioglu6, Soe Moe Aung7, Ali Bakan6, Ali Riza Odabas6. 1. a Department of Cardiology , Istanbul Medeniyet University Goztepe Training and Research Hospital , Istanbul , Turkey . 2. b Department of Neurology , Oltu Government Hospital , Istanbul , Turkey . 3. c Department of Radiology , Istanbul Medeniyet University Goztepe Training and Research Hospital , Istanbul , Turkey . 4. d Department of Cardiology , İstanbul Kartal Kosuyolu Yusek Ihtisas Training and Research Hospital , Istanbul , Turkey . 5. e Department of Internal Medicine , Istanbul Medeniyet University Goztepe Training and Research Hospital , Istanbul , Turkey . 6. f Department of Nephrology , Istanbul Medeniyet University Goztepe Training and Research Hospital , Istanbul , Turkey , and. 7. g Department of Cardiology , Istanbul Fatih University , Istanbul , Turkey.
Abstract
OBJECTIVE: AA amyloidosis occurs in the setting of longstanding inflammation. An increased incidence of coronary artery disease (CAD) was noted in patients with chronic inflammatory disease (CID). Retrobulbar blood flow predicts future macrovascular events including CAD. Increase in carotid artery intima-media thickness is regarded as a marker for early atherosclerosis. The relationship between chronic inflammation and atherosclerosis is well known; however, the connection between amyloidosis-advanced CIDs and retrobulbar microvascular function and carotid intima-media thickness (CIMT) is unidentified. We aimed to investigate whether retrobulbar microcirculation and CIMT were impaired or not in amyloidosis-advanced CID patients compared to normal subjects. METHODS: Fourteen patients with renal AA amyloidosis and a group of healthy volunteers were included in the study. Measurement of CIMT and retrobulbar blood flow velocities was performed with ultrasound scanner and color Doppler ultrasonography. RESULTS: The CIMT of patients with renal amyloidosis was significantly thicker than that of the normal population (p < 0.001). The resistivity index of the ophthalmic artery (OA) of patients with renal amyloidosis was significantly higher than the study group (p < 0.001). CONCLUSION: This study demonstrates that accelerated atherosclerosis which can be shown by increased OA resistivity index and CIMT are found in amyloidal-related CID patients.
OBJECTIVE: AA amyloidosis occurs in the setting of longstanding inflammation. An increased incidence of coronary artery disease (CAD) was noted in patients with chronic inflammatory disease (CID). Retrobulbar blood flow predicts future macrovascular events including CAD. Increase in carotid artery intima-media thickness is regarded as a marker for early atherosclerosis. The relationship between chronic inflammation and atherosclerosis is well known; however, the connection between amyloidosis-advanced CIDs and retrobulbar microvascular function and carotid intima-media thickness (CIMT) is unidentified. We aimed to investigate whether retrobulbar microcirculation and CIMT were impaired or not in amyloidosis-advanced CIDpatients compared to normal subjects. METHODS: Fourteen patients with renal AA amyloidosis and a group of healthy volunteers were included in the study. Measurement of CIMT and retrobulbar blood flow velocities was performed with ultrasound scanner and color Doppler ultrasonography. RESULTS: The CIMT of patients with renal amyloidosis was significantly thicker than that of the normal population (p < 0.001). The resistivity index of the ophthalmic artery (OA) of patients with renal amyloidosis was significantly higher than the study group (p < 0.001). CONCLUSION: This study demonstrates that accelerated atherosclerosis which can be shown by increased OA resistivity index and CIMT are found in amyloidal-related CID patients.
Entities:
Keywords:
AA amyloidosis; atherosclerosis; retrobulbar microcirculation