| Literature DB >> 26098743 |
Cassiana E Bittencourt, Jennifer P Ha, Robert W Maitta.
Abstract
Entities:
Year: 2015 PMID: 26098743 PMCID: PMC4476808 DOI: 10.1371/journal.pone.0131384
Source DB: PubMed Journal: PLoS One ISSN: 1932-6203 Impact factor: 3.240
Patient outcomes at UHCMC and comparison with relevant studies describing 30-day mortality and relapse.
| 2.Study | UHCMC 2008–2012 5 years | Levandovsky, et al. 1978–2002 24 years | Kim, et al. 1998–2008 10 years | Lara, et al. 1978–1998 20 years | George, et al 1989–2003 14.5 years | Roberts, et al. 1984–1990 6 years |
|---|---|---|---|---|---|---|
| Total cases (total cases used for mortality rate calculation) | 59 (59) | 178 (167)a | 52 (52) | 126 (124)c | 290 (214)e | 14 (14) |
| Idiopathic cause (%) | 75 | 72 | 27 | 71 | 39.3 | 43 |
| Secondary cause (%) | 25 | 28 | 73 | 29 | 60.7 | 57 |
| Age (mean* or median**) | 49* | 49* | 47* | 49* | 36**(f) | 45* |
| Gender (Female, %) | 70 | 68 | 61.5 | 66 | 71 | 50% |
| At presentation | ||||||
| Hemoglobin (mg/dL) mean* or median** | 9* | 9.2* | 7.6** | 8.9 * | NS | 9.8* |
| Serum creatinine (mg/dL) mean* or median** | 2.6* | 3.2* | 2.5** | 3,4** | 1.2 ** f | 5.7 g |
| Platelet (mean* or median**) | 46 x 109/L* | 49 x 109/L* | 30 x 109/L** | 44 x 109/L* | 11 x109/L** f | 50 x 109/L* |
| Clinical Severity Score (mean) | 4* | 4.4 | NS | 5 | NS | NS |
| Complete response (%) | 81.2 | 65 | 51.9 | 56 | 61h | NS |
| 30days-Relapse rate (%) | 18.6 | 18 | NS | 13 | 12 | 28.6 |
| TTP-HUS related deaths 30-days (number and %) | 4 (6.7%) | 23 (14%) b | 18 (34.6%) | 12 (10%) d | 38 (17%) | 1(7%) |
| TPE as principal treatment (%) | 100 | 96 | 100 | 97 | 100 | 100 |
| Others principal treatment | N/A | FFP infusion and Staphylococcal protein A absorption column | N/A | FFP infusion Protein adsorption column therapy | N/A | N/A |
| Number of TPE procedures (mean* or median**) | 12* | 8** | 5** | NS | 20 ** f | NS |
| TPE-Technique used | COBE Spectra | NS | COBE Spectra MFM (Plasauto) | Fenwal CS-3000 Blood Cell Separator Haemonetics model V50 Cobe Spectra | NS | NS |