Charles Champeaux1,2, Elena Wilson3, Sebastian Brandner4, Colin Shieff2, Lewis Thorne2. 1. a Department of Neurosurgery , Institute of Neurological Sciences , Glasgow , UK. 2. d Department of Neurosurgery , National Hospital for Neurology and Neurosurgery , London , UK. 3. b Department of Clinical Oncology , University College London Hospitals NHS Foundation Trust , London , UK. 4. c Department of Neuropathology , National Hospital for Neurology and Neurosurgery , London , UK.
Abstract
BACKGROUND: Anaplastic meningiomas are uncommon primary intracranial tumours associated with high level of recurrence and low life expectancy. Through three institutions experience, we analysed the clinical characteristics of patients with malignant meningiomas to determine their outcome and identify prognostic factors that may influence recurrence and survival. MATERIAL AND METHODS: A retrospective search identified 62 cases of WHO grade III meningiomas, of whom 9 (14.5%) were not considered in the survival analysis as no follow-up data were available. Thirty patients (48.4%) had a previous history of non-malignant meningioma surgery. The patients underwent a total of 139 surgical resections and 42 courses of radiotherapy of which 27 were given after the WHO grade III meningioma diagnosis. RESULTS: Eighteen patients (29.5%) were re-operated for a relapse of their anaplastic meningioma. Median time between the first and the second surgery was 1.3 years. Median overall survival time was 3.5 years. Overall survival probabilities at 1, 2 and 5 years were 74.6%, 95% confidence interval (CI) [63.8, 87.1], 58.7%, 95% CI [46.4, 74.3] and 37.7%, 95% CI [25, 56.8], respectively. Extent of resection was associated with the survival. DISCUSSION: This retrospective series highlights the poor prognosis associated with the diagnosis of malignant meningioma. Complete or subtotal resection may prolong the patients' survival. We could not confirm the usefulness of postoperative radiotherapy.
BACKGROUND:Anaplastic meningiomas are uncommon primary intracranial tumours associated with high level of recurrence and low life expectancy. Through three institutions experience, we analysed the clinical characteristics of patients with malignant meningiomas to determine their outcome and identify prognostic factors that may influence recurrence and survival. MATERIAL AND METHODS: A retrospective search identified 62 cases of WHO grade III meningiomas, of whom 9 (14.5%) were not considered in the survival analysis as no follow-up data were available. Thirty patients (48.4%) had a previous history of non-malignant meningioma surgery. The patients underwent a total of 139 surgical resections and 42 courses of radiotherapy of which 27 were given after the WHO grade III meningioma diagnosis. RESULTS: Eighteen patients (29.5%) were re-operated for a relapse of their anaplastic meningioma. Median time between the first and the second surgery was 1.3 years. Median overall survival time was 3.5 years. Overall survival probabilities at 1, 2 and 5 years were 74.6%, 95% confidence interval (CI) [63.8, 87.1], 58.7%, 95% CI [46.4, 74.3] and 37.7%, 95% CI [25, 56.8], respectively. Extent of resection was associated with the survival. DISCUSSION: This retrospective series highlights the poor prognosis associated with the diagnosis of malignant meningioma. Complete or subtotal resection may prolong the patients' survival. We could not confirm the usefulness of postoperative radiotherapy.
Entities:
Keywords:
grade III meningioma; malignant meningioma; outcome; prognostic factors; radiotherapy
Authors: Andrea D Maier; Jiri Bartek; Frank Eriksson; Heidi Ugleholdt; Marianne Juhler; Helle Broholm; Tiit I Mathiesen Journal: Neurosurg Rev Date: 2019-03-13 Impact factor: 3.042
Authors: Grace Collord; Patrick Tarpey; Natalja Kurbatova; Inigo Martincorena; Sebastian Moran; Manuel Castro; Tibor Nagy; Graham Bignell; Francesco Maura; Matthew D Young; Jorge Berna; Jose M C Tubio; Chris E McMurran; Adam M H Young; Mathijs Sanders; Imran Noorani; Stephen J Price; Colin Watts; Elke Leipnitz; Matthias Kirsch; Gabriele Schackert; Danita Pearson; Abel Devadass; Zvi Ram; V Peter Collins; Kieren Allinson; Michael D Jenkinson; Rasheed Zakaria; Khaja Syed; C Oliver Hanemann; Jemma Dunn; Michael W McDermott; Ramez W Kirollos; George S Vassiliou; Manel Esteller; Sam Behjati; Alvis Brazma; Thomas Santarius; Ultan McDermott Journal: Sci Rep Date: 2018-09-10 Impact factor: 4.379