Amy H Newton1,2, Derek B Danahy1,3, Marcia A Chan4, Stephen H Benedict1. 1. Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA. 2. Present address: Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, VA, USA. 3. Present address: Graduate Program in Immunology, University of Iowa, IA, USA. 4. Division of Allergy, Asthma & Immunology, Children's Mercy Hospitals & Clinics, MO, USA.
Abstract
AIM: It is becoming apparent that emphysema is partly driven by self-reactive T cells inducing inflammatory damage. Thus, T cells become targets for therapy similar to other autoimmune diseases. Costimulatory blockade therapy targets disease-specific T cells, rendering them ineffective by blocking a necessary costimulatory event on the T-cell surface. This therapy is tested here in mouse emphysema. MATERIALS & METHODS: Peptides representing contact domains of counter receptors LFA-1 and ICAM-1 were used as blockade therapy in elastase-induced emphysema. RESULTS: When administered during the first week after disease induction, blockade prevented lung destruction, reduced leukocyte infiltration and inhibited the decrease in T-cell CD4:CD8 ratio, also common in human emphysema. CONCLUSION: Costimulatory blockade therapy can affect the progress of emphysema.
AIM: It is becoming apparent that emphysema is partly driven by self-reactive T cells inducing inflammatory damage. Thus, T cells become targets for therapy similar to other autoimmune diseases. Costimulatory blockade therapy targets disease-specific T cells, rendering them ineffective by blocking a necessary costimulatory event on the T-cell surface. This therapy is tested here in mouseemphysema. MATERIALS & METHODS: Peptides representing contact domains of counter receptors LFA-1 and ICAM-1 were used as blockade therapy in elastase-induced emphysema. RESULTS: When administered during the first week after disease induction, blockade prevented lung destruction, reduced leukocyte infiltration and inhibited the decrease in T-cell CD4:CD8 ratio, also common in humanemphysema. CONCLUSION: Costimulatory blockade therapy can affect the progress of emphysema.
Authors: J Michael Wells; Laura A Colangelo; Lakshmi Sivarajan; Bharat Thyagarajan; Mark T Dransfield; Carlos Iribarren; Paul A Reyfman; David R Jacobs; George R Washko; Ravi Kalhan Journal: Eur Respir J Date: 2019-01-17 Impact factor: 16.671