Literature DB >> 26097797

The prognostic impact of specific CD4 T-cell responses is critically dependent on the target antigen in melanoma.

Henning Zelba1, Benjamin Weide2, Alexander Martens3, Jithendra Kini Bailur3, Claus Garbe2, Graham Pawelec3.   

Abstract

The melanoma-associated antigens Melan-A and NY-ESO-1 stimulate different T-cell responses in late-stage melanoma patients. Either CD4+ or CD8+ T-cell reactivity against NY-ESO-1 was associated with better prognosis, but for Melan-A, only CD8+ but not CD4+ T-cell responses were associated with longer survival.

Entities:  

Keywords:  MAGE-A3; Melan-A; NY-ESO-1; antigen-specific T-cells; intracellular cytokine staining; survivin

Year:  2015        PMID： 26097797      PMCID： PMC4431484          DOI： 10.4161/21624011.2014.955683

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.

Authors:  Naomi N Hunder; Herschel Wallen; Jianhong Cao; Deborah W Hendricks; John Z Reilly; Rebecca Rodmyre; Achim Jungbluth; Sacha Gnjatic; John A Thompson; Cassian Yee
Journal:  N Engl J Med       Date:  2008-06-19       Impact factor: 91.245

2.  Improved survival with ipilimumab in patients with metastatic melanoma.

Authors:  F Stephen Hodi; Steven J O'Day; David F McDermott; Robert W Weber; Jeffrey A Sosman; John B Haanen; Rene Gonzalez; Caroline Robert; Dirk Schadendorf; Jessica C Hassel; Wallace Akerley; Alfons J M van den Eertwegh; Jose Lutzky; Paul Lorigan; Julia M Vaubel; Gerald P Linette; David Hogg; Christian H Ottensmeier; Celeste Lebbé; Christian Peschel; Ian Quirt; Joseph I Clark; Jedd D Wolchok; Jeffrey S Weber; Jason Tian; Michael J Yellin; Geoffrey M Nichol; Axel Hoos; Walter J Urba
Journal:  N Engl J Med       Date:  2010-06-05       Impact factor: 91.245

3.  Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.

Authors:  Jérôme Galon; Anne Costes; Fatima Sanchez-Cabo; Amos Kirilovsky; Bernhard Mlecnik; Christine Lagorce-Pagès; Marie Tosolini; Matthieu Camus; Anne Berger; Philippe Wind; Franck Zinzindohoué; Patrick Bruneval; Paul-Henri Cugnenc; Zlatko Trajanoski; Wolf-Herman Fridman; Franck Pagès
Journal:  Science       Date:  2006-09-29       Impact factor: 47.728

4.  Functional T cells targeting NY-ESO-1 or Melan-A are predictive for survival of patients with distant melanoma metastasis.

Authors:  Benjamin Weide; Henning Zelba; Evelyna Derhovanessian; Annette Pflugfelder; Thomas K Eigentler; Anna Maria Di Giacomo; Michele Maio; Erik H J G Aarntzen; I Jolanda M de Vries; Antje Sucker; Dirk Schadendorf; Petra Büttner; Claus Garbe; Graham Pawelec
Journal:  J Clin Oncol       Date:  2012-04-23       Impact factor: 44.544

5.  Myeloid-derived suppressor cells predict survival of patients with advanced melanoma: comparison with regulatory T cells and NY-ESO-1- or melan-A-specific T cells.

Authors:  Benjamin Weide; Alexander Martens; Henning Zelba; Christina Stutz; Evelyna Derhovanessian; Anna Maria Di Giacomo; Michele Maio; Antje Sucker; Bastian Schilling; Dirk Schadendorf; Petra Büttner; Claus Garbe; Graham Pawelec
Journal:  Clin Cancer Res       Date:  2013-12-09       Impact factor: 12.531

6.  Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma.

Authors:  Henning Zelba; Benjamin Weide; Alexander Martens; Evelyna Derhovanessian; Jithendra Kini Bailur; Christina Kyzirakos; Annette Pflugfelder; Thomas K Eigentler; Anna Maria Di Giacomo; Michele Maio; Erik H J G Aarntzen; Jolanda de Vries; Antje Sucker; Dirk Schadendorf; Petra Büttner; Claus Garbe; Graham Pawelec
Journal:  Clin Cancer Res       Date:  2014-06-17       Impact factor: 12.531

7.  T-helper-1-cell cytokines drive cancer into senescence.

Authors:  Heidi Braumüller; Thomas Wieder; Ellen Brenner; Sonja Aßmann; Matthias Hahn; Mohammed Alkhaled; Karin Schilbach; Frank Essmann; Manfred Kneilling; Christoph Griessinger; Felicia Ranta; Susanne Ullrich; Ralph Mocikat; Kilian Braungart; Tarun Mehra; Birgit Fehrenbacher; Julia Berdel; Heike Niessner; Friedegund Meier; Maries van den Broek; Hans-Ulrich Häring; Rupert Handgretinger; Leticia Quintanilla-Martinez; Falko Fend; Marina Pesic; Jürgen Bauer; Lars Zender; Martin Schaller; Klaus Schulze-Osthoff; Martin Röcken
Journal:  Nature       Date:  2013-02-03       Impact factor: 49.962

8.  Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma.

Authors:  Luis Vence; A Karolina Palucka; Joseph W Fay; Tomoki Ito; Yong-Jun Liu; Jacques Banchereau; Hideki Ueno
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-18       Impact factor: 11.205

9.  Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.

Authors:  Andreas Bonertz; Jürgen Weitz; Dong-Ho Kim Pietsch; Nuh N Rahbari; Christoph Schlude; Yingzi Ge; Simone Juenger; Israel Vlodavsky; Khashayarsha Khazaie; Dirk Jaeger; Christoph Reissfelder; Dalibor Antolovic; Maximilian Aigner; Moritz Koch; Philipp Beckhove
Journal:  J Clin Invest       Date:  2009-10-05       Impact factor: 14.808

10.  High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.

Authors:  M J Pittet; D Valmori; P R Dunbar; D E Speiser; D Liénard; F Lejeune; K Fleischhauer; V Cerundolo; J C Cerottini; P Romero
Journal:  J Exp Med       Date:  1999-09-06       Impact factor: 14.307
  10 in total
  3 in total

Review 1.  Melanoma: oncogenic drivers and the immune system.

Authors:  Niki Karachaliou; Sara Pilotto; Cristina Teixidó; Santiago Viteri; María González-Cao; Aldo Riso; Daniela Morales-Espinosa; Miguel Angel Molina; Imane Chaib; Mariacarmela Santarpia; Eduardo Richardet; Emilio Bria; Rafael Rosell
Journal:  Ann Transl Med       Date:  2015-10

Review 2.  Advances in Proteomic Techniques for Cytokine Analysis: Focus on Melanoma Research.

Authors:  Helena Kupcova Skalnikova; Jana Cizkova; Jakub Cervenka; Petr Vodicka
Journal:  Int J Mol Sci       Date:  2017-12-13       Impact factor: 5.923

3.  Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma.

Authors:  Juan Fang; Xiaoxu Li; Da Ma; Xiangqi Liu; Yichen Chen; Yun Wang; Vivian Wai Yan Lui; Juan Xia; Bin Cheng; Zhi Wang
Journal:  BMC Cancer       Date:  2017-05-26       Impact factor: 4.430
  3 in total

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