| Literature DB >> 26097593 |
Xinqiong Huang1, Miaomiao Liu1, Hong Sun2, Fengjun Wang2, Xiaoxue Xie3, Xiang Chen4, Juan Su4, Yuxiang He1, Youyi Dai1, Haijun Wu1, Liangfang Shen1.
Abstract
The mechanism by which overexpression of hexokinase 2 (HK2) indicates locally advanced cervical squamous cell carcinoma (LACSCC) with radio-resistance is still unknown despite being an independent biomarker of poor prognosis. Here, we retrospectively analyzed 132 female patients receiving radiotherapy for cervical squamous cell carcinoma including 85 radiation-sensitive cases and 47 radiation-resistant cases. The expression of HK2 was examined by immunohistochemistry. The percentage of high HK2 expression in the radiation-resistant group differed from the radiation-sensitive group with statistical significance (P < 0.001) even if divided into three subgroups including a lower 5-year progression free survival group (PFS) for comparison (P < 0.001). The Kaplan Meier curve analysis showed that there were differences between the two groups (P < 0.001). Therefore, this study proves a close relationship between HK2 expression and radio-resistance. Multivariate Cox regression analysis implied that HK2 was an independent prognostic indicator of cervical squamous carcinoma (HR (95% CI), 2.940 (1.609, 1.609); P = 0.002).Entities:
Keywords: HK2; Locally advanced cervical squamous cell carcinoma; glycolysis; immunohistochemistry; radiation resistance
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Year: 2015 PMID： 26097593 PMCID： PMC4466980
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625