| Literature DB >> 26097569 |
Zhong Jin1, Naijin Xu2, Kai Guo1, Peng Xu1, Pengju Li1, Yiming Zhang1, Xiezhao Li1, Shaobo Zheng1, Chunxiao Liu1, Abai Xu1, Peng Huang1.
Abstract
Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is an independent prognostic indicator of metastasis, which has recently gained considerable attention in cancer research, due to its overexpression in several types of carcinoma. However, MACC1 expression patterns and its possible role in renal cell carcinoma remain unknown. This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P < 0.05). A Kaplan-Meier survival analysis revealed that patients with higher MACC1 expression had a significantly lower disease-free rate (P < 0.05). These results indicate that MACC1 expression is significantly associated with prognosis in patients with renal cell carcinoma. To the best of our knowledge, this is the first study on the significance of MACC1 as a prognostic marker in renal cell carcinoma. MACC1 expression may be a useful target for the development of new therapeutic approaches, including molecular targeted therapeutic agents, for renal cell carcinoma.Entities:
Keywords: MACC1; biomarker; prognosis; renal cell carcinoma
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Year: 2015 PMID： 26097569 PMCID： PMC4466956
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625