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Literature DB >> 26097553

HGF/MET signaling promotes glioma growth via up-regulation of Cox-2 expression and PGE2 production.

Yan Zhao¹, Ying Sun¹, Haiyan Zhang², Xing Liu¹, Wenzong Du¹, Yongli Li¹, Junhe Zhang¹, Lingchao Chen³, Chuanlu Jiang¹.

Abstract

Cyclooxygenase2 (Cox-2) is well known for glioma growth through up-regulation of prostaglandin E2 (PGE2) levels. MET, a hepatocyte growth factor (HGF) receptor, is also frequently high expressed in glioma, which promotes glioma growth and invasion. Here, we demonstrate that HGF/MET signaling can promote PGE2 production in glioma cells via Cox-2 up-regulation. RNA inhibition of MET suggested that MET signaling is essential for Cox-2 up-regulation. Moreover, HGF could enhance Cox-2 expression and PGE2 release. Knockdown of Cox-2 inhibited growth-promoting effects of HGF, suggesting that HGF/MET functioned via Cox-2/PGE2 pathway. Therefore, our work reveals a critical relationship of Cox-2/PGE2 and HGF/MET signaling in promoting glioma cells proliferation. Further, targeting MET and Cox-2 may represent an attractive target therapy for glioma.

Entities: Chemical Disease Gene

Keywords: Cox-2; GBMs; MET; PGE2

Mesh：

Substances：

Year: 2015 PMID： 26097553 PMCID： PMC4466940

Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625

31 in total

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Journal: J Clin Oncol Date: 2011-03-07 Impact factor: 44.544

5. Altered eicosanoid levels in human colon cancer.

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6. In Vivo c-Met Pathway Inhibition Depletes Human Glioma Xenografts of Tumor-Propagating Stem-Like Cells.

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Authors: Paolo M Comoglio; Silvia Giordano; Livio Trusolino
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8. Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors.

Authors: Rama Pai; Toshikazu Nakamura; Woo S Moon; Andrzej S Tarnawski
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9. Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma.

Authors: Ryoichi Fujii; Yorihisa Imanishi; Katsushi Shibata; Nobuya Sakai; Koji Sakamoto; Seiji Shigetomi; Noboru Habu; Kuninori Otsuka; Yoichiro Sato; Yoshihiro Watanabe; Hiroyuki Ozawa; Toshiki Tomita; Kaori Kameyama; Masato Fujii; Kaoru Ogawa
Journal: J Exp Clin Cancer Res Date: 2014-05-10

10. COX-2 overexpression increases malignant potential of human glioma cells through Id1.

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4 in total

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