Peixin Lin1, Lulu Gao1, Yeen Huang1, Qing Chen2, Hong Shen1. 1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University Tonghe, Guangzhou, China. 2. Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University Tonghe, Guangzhou, China.
Abstract
OBJECTIVE: To study the target organs for enterovirus 71 (EV71) in infected suckling mice. METHODS: 5-day-old BALB/c suckling mice were infected with an EV71 strain. Tissues of the infected mice were processed for histopathological examination, including immunohistochemistry, in situ hybridization, ultrastructural observation. RESULTS: Some mice developed limb paralysis, trouble walking and loss of balance. Results of the histopathological study showed that a large amount of EV71 existed in the skeletal muscle tissues, accounting for the damage of the skeletal muscles. CONCLUSION: The EV71 clinical isolate used in this study presented evident myotropism. Skeletal muscles are important target organs for EV71 in the infected suckling mice. To clarify the relationship between EV71 infection and muscle diseases may contribute to a better understanding of the pathogenesis of EV71.
OBJECTIVE: To study the target organs for enterovirus 71 (EV71) in infected suckling mice. METHODS: 5-day-old BALB/c suckling mice were infected with an EV71 strain. Tissues of the infected mice were processed for histopathological examination, including immunohistochemistry, in situ hybridization, ultrastructural observation. RESULTS: Some mice developed limb paralysis, trouble walking and loss of balance. Results of the histopathological study showed that a large amount of EV71 existed in the skeletal muscle tissues, accounting for the damage of the skeletal muscles. CONCLUSION: The EV71 clinical isolate used in this study presented evident myotropism. Skeletal muscles are important target organs for EV71 in the infected suckling mice. To clarify the relationship between EV71 infection and muscle diseases may contribute to a better understanding of the pathogenesis of EV71.
Authors: M Chumakov; M Voroshilova; L Shindarov; I Lavrova; L Gracheva; G Koroleva; S Vasilenko; I Brodvarova; M Nikolova; S Gyurova; M Gacheva; G Mitov; N Ninov; E Tsylka; I Robinson; M Frolova; V Bashkirtsev; L Martiyanova; V Rodin Journal: Arch Virol Date: 1979 Impact factor: 2.574