Literature DB >> 26097131

Inhibition of Cancer Cell Migration by Multiwalled Carbon Nanotubes.

Lorena García-Hevia1, Rafael Valiente2, José L Fernández-Luna3, Emmanuel Flahaut4, Lidia Rodríguez-Fernández5, Juan C Villegas6, Jesús González7, Mónica L Fanarraga1.   

Abstract

Inhibiting cancer cell migration and infiltration to other tissues makes the difference between life and death. Multiwalled carbon nanotubes (MWCNTs) display intrinsic biomimetic properties with microtubules, severely interfering with the function of these protein filaments during cell proliferation, triggering cell death. Here it is shown MWCNTs disrupt the centrosomal microtubule cytoskeletal organization triggering potent antimigratory effects in different cancer cells.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  biomechanics; cancer; cytoskeleton; metastasis; tubulin polymers

Mesh：

Substances：

Year:  2015        PMID： 26097131     DOI： 10.1002/adhm.201500252

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  8 in total

1.  Immunostimulatory CpG on Carbon Nanotubes Selectively Inhibits Migration of Brain Tumor Cells.

Authors:  Darya Alizadeh; Ethan E White; Teresa C Sanchez; Shunan Liu; Leying Zhang; Behnam Badie; Jacob M Berlin
Journal:  Bioconjug Chem       Date:  2018-04-02       Impact factor: 4.774

2.  Gb3/cd77 Is a Predictive Marker and Promising Therapeutic Target for Head and Neck Cancer.

Authors:  Lorena García-Hevia; Débora Muñoz-Guerra; Íñigo Casafont; Carmelo Morales-Angulo; Victor J Ovejero; David Lobo; Mónica L Fanarraga
Journal:  Biomedicines       Date:  2022-03-22

Review 3.  Advances in Carbon Nanotubes for Malignant Melanoma: A Chance for Treatment.

Authors:  Elidamar Nunes de Carvalho Lima; José Roberto Castilho Piqueira; Durvanei Augusto Maria
Journal:  Mol Diagn Ther       Date:  2018-12       Impact factor: 4.074

4.  Carbon nanotubes gathered onto silica particles lose their biomimetic properties with the cytoskeleton becoming biocompatible.

Authors:  Elena González-Domínguez; Nerea Iturrioz-Rodríguez; Esperanza Padín-González; Juan Villegas; Lorena García-Hevia; Moisés Pérez-Lorenzo; Wolfgang J Parak; Miguel A Correa-Duarte; Mónica L Fanarraga
Journal:  Int J Nanomedicine       Date:  2017-08-29

Review 5.  Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment.

Authors:  Lorena García Hevia; Mónica L Fanarraga
Journal:  J Nanobiotechnology       Date:  2020-12-14       Impact factor: 10.435

6.  Multiwalled carbon nanotubes inhibit cell migration and invasion by destroying actin cytoskeleton via mitochondrial dysfunction in ovarian cancer cells.

Authors:  Ping Zhang; Jiangyan Teng; Lijuan Wang
Journal:  Aging (Albany NY)       Date:  2020-12-03       Impact factor: 5.682

7.  The unpredictable carbon nanotube biocorona and a functionalization method to prevent protein biofouling.

Authors:  Lorena García-Hevia; Mahsa Saramiforoshani; Jorge Monge; Nerea Iturrioz-Rodríguez; Esperanza Padín-González; Fernando González; Lorena González-Legarreta; Jesús González; Mónica L Fanarraga
Journal:  J Nanobiotechnology       Date:  2021-05-05       Impact factor: 10.435

8.  MSN, MWCNT and ZnO nanoparticle-induced CHO-K1 cell polarisation is linked to cytoskeleton ablation.

Authors:  Karmveer Yadav; Syed Azmal Ali; Ashok Kumar Mohanty; Eshwarmoorthy Muthusamy; Kesavan Subaharan; Gautam Kaul
Journal:  J Nanobiotechnology       Date:  2021-02-12       Impact factor: 10.435
  8 in total

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