Azar Nickavar1, Baranak Safaeian2, Simin Sadeghi-Bojd3, Arash Lahouti Harah dashti4. 1. Department of Pediatric Nephrology, Iran University Medical Sciences, Tehran, Iran. 2. Department of Pediatrics, Gorgan University Medical Sciences, Gorgan, Iran. Safaeian26@gmail.com. 3. Department of Pediatrics, Zahedan University Medical Sciences, Zahedan, Iran. 4. Department of Medicine, Iran University Medical Sciences, Tehran, Iran.
Abstract
OBJECTIVE: To find the value of urine neutrophil gelatinase associated lipocalin (NGAL) in differentiating steroid response in children with idiopathic nephrotic syndrome (INS). METHODS: A total of 52 children with INS (n = 27, steroid resistant; n = 25, steroid responsive) aged 1-16 y, along with 18 healthy control children were enrolled in this study. Urine NGAL as well as urine protein, and serum creatinine were analyzed during active phase of INS. RESULTS: Serum creatinine (P 0.032), and urine NGAL/Cr (P 0.001) were significantly higher in steroid resistant than steroid sensitive patients. The optimal cutoff value for urine NGAL/Cr with the highest sensitivity and specificity was 0.46 ng/mg and cut off value of 0.01 and 1.15 ng/mg had maximum sensitivity and specificity, respectively. CONCLUSIONS: Urine NGAL/Cr could be considered as a marker of steroid resistance in children with idiopathic nephrotic syndrome.
OBJECTIVE: To find the value of urine neutrophil gelatinase associated lipocalin (NGAL) in differentiating steroid response in children with idiopathic nephrotic syndrome (INS). METHODS: A total of 52 children with INS (n = 27, steroid resistant; n = 25, steroid responsive) aged 1-16 y, along with 18 healthy control children were enrolled in this study. Urine NGAL as well as urine protein, and serum creatinine were analyzed during active phase of INS. RESULTS: Serum creatinine (P 0.032), and urine NGAL/Cr (P 0.001) were significantly higher in steroid resistant than steroid sensitive patients. The optimal cutoff value for urine NGAL/Cr with the highest sensitivity and specificity was 0.46 ng/mg and cut off value of 0.01 and 1.15 ng/mg had maximum sensitivity and specificity, respectively. CONCLUSIONS: Urine NGAL/Cr could be considered as a marker of steroid resistance in children with idiopathic nephrotic syndrome.
Authors: Jung Sue Kim; Christine A Bellew; Douglas M Silverstein; Diego H Aviles; Frank G Boineau; V Matti Vehaskari Journal: Kidney Int Date: 2005-09 Impact factor: 10.612
Authors: Thomas L Nickolas; Catherine S Forster; Meghan E Sise; Nicholas Barasch; David Solá-Del Valle; Melanie Viltard; Charles Buchen; Shlomo Kupferman; Maria Luisa Carnevali; Michael Bennett; Silvia Mattei; Achiropita Bovino; Lucia Argentiero; Andrea Magnano; Prasad Devarajan; Kiyoshi Mori; Hediye Erdjument-Bromage; Paul Tempst; Landino Allegri; Jonathan Barasch Journal: Kidney Int Date: 2012-06-13 Impact factor: 10.612